There has been significant progress toward clinically relevant levels of retroviral gene transfer into hematopoietic stem cells (HSC), and the therapeutic ... Kiem,H - 《Molecular Therapy》 被引量: 172发表: 2004年 Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in...
This chapter discusses the structure and functions of hematopoietic tissues such as bone marrow, spleen, and lymph nodes. Bone marrow is a mesenchymal-derived complex structure consisting of hematopoietic precursors and a complex microenvironment that facilitates the maintenance of hematopoietic stem cells ...
Hematopoietic stem cells (HSCs) are responsible for the production of mature blood cells in bone marrow; peripheral pancytopenia is a common clinical presentation resulting from several different conditions, including hematological or extra-hematological diseases (mostly cancers) affecting the marrow function...
Expression and function of adhesion molecules on human hematopoietic stem cells: CD34+ LFA-1- cells are more primitive than CD34+ LFA-1+ cells. Blood 1992; 80: 429-436 [PMID: 1378320]Gunji Y,Nakamula M,Hagiwara T,et al.Expression and function of adhesion molecules on human hematopoietic ...
To test function of hematopoietic stem cells (HSCs) in vivo in C57BL/6 (B6) and Trp53-deficient (Trp53 null) mice by using two HSC enrichment schemes. Bone marrow (BM) Lin CD41 CD48 CD150 + (signaling lymphocyte activation molecules [SLAM]), Lin CD41 CD48 CD150 (SLAM ) and Lin ...
Mice homozygous for the autosomal recessive mutation "motheaten" have normal numbers of multipotential hematopoietic stem cells in the bone marrow and spleen as determined by spleen colony assay. Histologic examination shows no qualitative abnormality in morphology of stem cell colonies in recipients of...
Expression and function of adhesion molecules on human hematopoietic stem cells: CD34+ LFA-1-cells are more primitive than CD34+ LFA-1+ cells. Blood 80:429-436, 1992.Gunji Y, Nakamura M, Hagiwara T, Hayakawa K, Matsus- hita H... Y Gunji,M Nakamura,T Hagiwara,... - 《Blood》 被引...
Mesenchymal stem cells (MSC) are a rare subset of stem cells residing in the bone marrow where they closely interact with hematopoietic stem cells and support their growth and differentiation. MSC can differentiate into multiple mesenchymal and non-mesenchymal lineages, providing a promising tool for...
Homing of hematopoietic stem cells (HSCs) into hematopoietic organs is a prerequisite for the establishment of hematopoiesis during embryogenesis and after bone marrow transplantation. We show that β1 integrin–deficient HSCs from the para-aortic splanchnopleura and the fetal blood had hematolymphoid ...
Natural killer (NK) cells participate in innate and adaptive immune responses, and upon activation rapidly produce cytokines, chemokines, and growth factors, including IFNγ, TNFα, TGFβ, GM-CSF, MIP1α, MIP1β, IL-10, and others, which can affect the function of other hematopoietic cells...