Structure and Function of Glutamate Dehydrogenase During Transient Senescence of Mustard (Sinapis Alba L.) CotyledonsGlutamate dehydrogenase (GDH, EC 1.4.1.3) catalyses the reductive amination of 2-oxoglutarate to glutamate (NADH-GDH) especially under conditions of ample ammonia supply (Yamaya and ...
Reactions were quenched in a boiling water bath for 1 min and glutamate was determined by the glutamate dehydrogenase method (Messenger and Zalkin, 1979). A basal PRPP-independent glutaminase activity was determined by the same procedure except for omission of PRPP in the reaction. PRPP-dependent ...
as shown by heatmap analysis of metabolism-related genes (Fig.1C). Glutamine is taken into cells by transporters SLC1A4 or SLC1A5. Then glutamine is converted to glutamate in mitochondria by GLS1, the key rate-
In addition to upregulating Bcl-2 expression, recent studies have suggested that IL-7 and IL-15 also regulate memory T cell metabolism. IL-7 and, to a lesser extent, IL-15, induce the expression of the glycerol channel aquaporin-9 on memory CD8 + T cells after LCMV infection (Fig....
In this regard, large projects aimed at deciphering the genetic changes occurring in tumors are being questioned due to their limited applicability for the development of effective therapies [1]. These arguments [1], [2] suggest that the development of an effective therapy against cancer will ...
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here...
The injured mice were treated with lactate, 4-CIN (a monocarboxylate transporter 2 inhibitor that can obstruct lactate transport into cells), and OX (an inhibitor of lactate dehydrogenase that can inhibit lactate production) after SCI (Fig. 3A). We found that lactate treatment increased lactate ...
gain of function mutant 功能突变体的获得 例句：1.Central nervous system hyperexcitability associated with glutamate dehydrogenasegain of function mutations 中枢神经系统兴奋性过高与谷氨酸脱氢酶获得性功能突变 2.Five IGFBP 3 mutants were generated after DNA sequence analysis, then theinteractions ...
lower potential for gluconeogenesis (lower fructose diphosphatase: phosphofructokinase ratios), and lower activities of enzymes in oxidative metabolism (citrate synthase, malate dehydrogenase, aspartate aminotransferase, and glutamate dehydrogenase) and in the pentose shunt (glucose-6-phosphate dehydrogenase). ...
The functions attributed to specific neurosteroids include modulation of GABAA and NMDA function, modulation of σ receptor function, regulation of myelinization, neuroprotection, and growth of axons and dendrites. Neurosteroids have also been shown to modulate expression of particular subunits of GABAA ...