Gene expressionHistone modificationNucleosome remodelingStem cellTranscription regulationChromatin by its nature presents a major obstacle to all processes occurring in the nucleus: transcription, DNA repair, and replication. At local level, intimate interactions of DNA with the core histones render it less...
A faster way is to instead identify the function of genes by comparing them to the smaller set of genes with known function. This comparison may be based on many different kinds of data, including sequence similarity and gene expression data. The goal of this dissertation is to provide tools...
11.1Studyingthetranscriptofaclonedgene11.1.1Electronmicroscopyofnucleicacidmolecules11.1.2AnalysisofDNA-RNAhybridsbynucleasetreatment11.1.3Transcriptanalysisbyprimerextension11.1.4OthertechniquesforstudyingRNAtranscripts11.2Studyingtheregulationofgeneexpression11.2.1IdentifyingproteinbindingsitesonaDNAmolecule11.2....
D. Finding the target sites of RNA-binding proteins. Wiley Interdiscip. Rev. RNA 5, 111–130 (2014). Article Google Scholar Zeraati, M. et al. Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression. Sci. Rep. 7, 708 (2017). Article Google ...
RG4s can be very stable in vitro in the presence of cations such as potassium (K+); therefore, they are hypothesized to exist in vivo and to be involved in novel functions [5], such as post-transcriptional regulation of gene expression [7,8,9]. Nevertheless, the lack of direct ...
Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. PURPOSE: Individual differences in patterns of gene expression account for much of the diversity of ocular phenotypes and variation in disease risk. We exa... EE Geisert,L Lu,NE Freeman-Anderson,......
Objective To establish the prokaryotic expression vector of human gene C16orf68,and get the C16orf68 recombinant protein.To prepare the C16orf68 specific rabbit polyclonal antibody,and observe the expression of C16orf68 in different cell lines.Methods C16orf68 cDNA was gotten from LX2 cells and ...
Daily, rhythmic variation in various biochemical, physiological, and behavioral events is a fundamental property of biological organization. Here, we report analysis of relative levels of gene expression in the liver of 16 Fischer 344 rats as a function of time of day. Expression levels were determ...
预测noncoding variant与基因表达的工具已经很多了,且在eQTL数据上面的表现已经不错了。 CshlSiepelLab/FitCons2 FIRE: functional inference of genetic variants that regulate gene expression 马上深入探索~
To further analyze the functional genomics data of apple genes, the AppleGFDB was designed to enable users to easily retrieve information through a suite of interfaces, including gene ontology, protein domain and InterPro. In addition, the database provides tools for analyzing the expression ...