We tested our hypothesis that dopamine (DA) is secreted from the brain to the blood during the perinatal period of rat ontogeny when rats have no blood-brain barrier. We developed a specific pharmacological model to inhibit DA synthesis in the brain and maintain its constant level on the ...
Medicines that increase the amount of dopamine in the brain can help combat symptoms of the disease, according to the National Institute of Aging. Bell’s Palsy Major nerves spread outward from the central nervous system to various organs and tissues, with each powering specific functions. Cranial...
Drug misuse and addiction.Drugs such as cocaine can cause a big, fast increase of dopamine in your brain. That satisfies your natural reward system in a big way. But repeated drug use also raises the threshold for this kind of pleasure. This means you need to take more to get the same...
Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. A number of studies over the last two decades have demonstrated the critical importance of dopamine (DA) in the behavioral pharmacology and addictive prope... Zhu,ME A,Reith - 《Cns & Ne...
Recent advances in molecular biology have resulted in a number of genetically manipulated mice with defined changes at dopamine receptor and the dopamine transporter (DAT) loci. Mice with targeted mutations at the D1 receptor (D1R) are growth-retarded and show downregulated expression of dynorphin ...
The areas of the brain where dopamine is produced include the substantia nigra, the ventral tegmental area, and the hypothalamus. Note that these regions are minuscule in comparison to the rest of the brain.What does Dopamine do? Effects of Dopamine on the Brain Effects of Low Dopamine Levels...
The Role of Dopamine in the Pathophysiology of Depression. Arch Gen Psychiatry. 2007;64:327–37. 50. Ryding E, Lindström M, Träskman-Bendz L. The role of dopamine and serotonin in suicidal behaviour and aggression. In: Di Giovann G, Di Matteo V, Esposito E, (eds). Progress in ...
N-Acetyl-L-aspartic acid in brain TALLAN HH, MOORE S, STEIN WH. HH Tallan,S Moore,WH Stein - 《Journal of Biological Chemistry》 被引量: 872发表: 1956年 The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia. BACKGROUND: Pathol...
Dopamine (DA) autoreceptors expressed along the somatodendritic extent of midbrain DA neurons modulate impulse activity, whereas those expressed at DA nerve terminals regulate both DA synthesis and release. Considerable evidence has indicated that these DA autoreceptors are of the D2 subtype of DA re...
Impulsivity, in vivo DAT function and extracellular dopamine concentration did not predict DIO. Importantly, motivation for high-fat reinforcers predicted the development of DIO. Conclusion: Human studies are limited by their ability to determine if impulsivity, motivation and DAT function are causes ...