Cyclin D1 is a multifunctional protein that is able to interact with pRb via a conserved LxCxE pRb binding motif, activate a kinase partner and direct the phosphorylation of pRb, activate cyclin E-cdk2 by titrating Cip/Kip cdk inhibitors, and modulate the activity of a variety of ...
Cyclin D1 is a cell-cycle regulator essential for G1 phase progression and a candidate proto-oncogene implicated in pathogenesis of several human tumour types, including breast carcinomas. In spite of the accumulating genetic evidence, however, there are no data regarding abundance and properties of...
Cyclin D1 is a cell-cycle regulator essential for G1 phase progression and a candidate proto-oncogene implicated in pathogenesis of several human tumour types, including breast carcinomas. In spite of the accumulating genetic evidence, however, there are
Furthermore, both the butyrate-containing supernatant of S2T10D and glucose-deprived cell culture medium supplemented with the same concentration of butyrate found in S2T10D supernatant, induced a pH-independent cancer cell growth inhibition accompanied by downregulation of cyclin D1 at mRNA level. The...
Cyclin D1 determines estrogen signaling in the mammary gland in vivo. The CCND1 gene, which is frequently overexpressed in cancers, encodes the regulatory subunit of a holoenzyme that phosphorylates the retinoblastoma protein... MC Casimiro,C Wang,Z Li,... - 《Molecular Endocrinology》...
Mack, D. Maetzel, H. Kremling, C. Eggert, U. Harréus, O. Gires EpCAM regulates cell cycle progression via control of cyclin D1 expression Oncogene (2012), pp. 1-10 Google Scholar [78] M. Münz, R. Zeidler, O. Gires The tumour-associated antigen EpCAM upregulates the fatty ...
Differential Expression of Cyclin D1 in Breast Papillary Carcinomas an... OBJECTIVES: Distinguishing intraductal papilloma from papillary carcinoma of the breast can be difficult using histologic criteria. Since cyclin D1, a G1 c... M Saddik,R Lai,LJ Medeiros,... - 《Archives of Pathology &...
PTHrP induced a proliferative cyclin D1 activation in low-density osteoblastic cells. The process was PKA and MAPK dependent and involved both AP-1 and CRE... NS Datta,GJ Pettway,C Chen,... - 《Journal of Bone & Mineral Research》 被引量: 136发表: 2010年 Immunocytochemical evidence on th...
Blockage of Wnt pathway by Delta-NTCF4, a dominant negative TCF4, could suppress BEL-7402 cells growth and decrease the expression of cyclin D1 and c-myc, two of target genes of Wnt pathway. On the other hand, stimulating Wnt pathway by introducing a degradation-resistant -catenin S37A ...
As for the molecular mechanisms involved, they largely involve both positive actions on genes such as the p16INK4alpha cyclin-dependent kinase inhibitor and negative effects on genes such as cyclin D1 during the G1-phase of the cell cycle. However, JunB is also endowed with a cell-division...