Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 1998; 396: 687±90.Schroeder BC, Kubisch C, Stein V, Jentsch TJ. Moderate loss of function of cyclic-AMP- modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 1998; 396: 687-690...
of the respective homomeric channels. KCNQ2/KCNQ3 currents can be increased by intracellular cyclic AMP, an effect that depends on an intact phosphorylation site in the KCNQ2 amino terminus. KCNQ2 and KCNQ3 mutations identified in BFNC pedigrees compromised the function of the respective subunits,...
We predict that a 25% loss of heteromeric KCNQ2/KCNQ3-channel function is sufficient to cause the electrical hyperexcitability in BFNC. Drugs raising intracellular cAMP may prove beneficial in this form of epilepsy. 展开 关键词: Cyclic AMP Epilepsy Potassium Channels DNA Complementary KCNQ2-...
Cyclic AMP, renal function and dihydralazine-stimulated renin secretion in hypertensive patientsrenovascular hypertensiondiagnostic procedureThe concentrations of plasma cAMP and plasma renin activity were determined in arterial and renal venous plasma in nineteen patients investigated for renin-mediated ...
In recent decades, there has been increasing evidence linking the dysregulation of cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING)-related immune signaling to liver disorders. Both hyperactivation and deletion of STING can disrupt the immune microenvironment dysfunction, exacerbating ...
Cyclic Nucleotides, Phosphorylated Proteins, and Neuronal Function - Greengard - 1978 () Citation Context ...hat several neurotransmitters and neuromodulators may mediate some of their effects through the “second messengers” cyclic AMP, cyclic GMP, and calcium (for reviews, see Bloom, 1975; ...
there has been increasing evidence linking the dysregulation of cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING)-related immune signaling to liver disorders. Both hyperactivation and deletion of STING can disrupt the immune microenvironment dysfunction, exacerbating liver disorders. Cons...
The manifestations of peptic ulcer disease constitute some of the commonest medical complaints. However, while potent pharmacological therapies targeted at the...
Dziak - 《Journal of Cellular Physiology》 被引量: 131发表: 1976年 Different roles for calcium and cyclic AMP in the action of PTH: Studies in bone explants and isolated bone cells In fetal mouse calvaria forskolin (0.1–100 μM), like PTH, stimulated cyclic AMP production in a dose-depen...
Activation of mouse 尾-cell CB1 and CB2 receptors resulted in decreased cyclic AMP, increased calcium and potentiation of glucose-stimulated insulin secretion. Thus, activation of islet cannabinoid receptors by locally produced endocannabinoids such as 2-aminoglycerol may be another regulatory pathway by...