Structure–function analysis of rods and cones in juvenile, adult, and aged C57BL/6 and Balb/c miceAnimalsMice, Inbred BALB CMice, Inbred C57BLMiceAlbinismElectroretinographyAgingCell SurvivalRetinal Rod Photoreceptor CellsRetinal Cone Photoreceptor Cells...
Cilia are extracellular organelles that protrude from the cell surface and are present in the epithelial cells lining every organ. The cilium structure is conserved, containing a ciliary membrane and microtubule-based axoneme. There are two types of cilia, including 9+2 motile cilia and 9+0 pri...
4d). This is consistent with the cellular organisation of the retina over the eye as the density of rod and cone photoreceptors is maximal in the submacular area and decreases towards the periphery49. From (2) and (5), variations in the shape of functional vascular segments may also ...
(MPTP) mouse model of PD to characterize the neurotoxic effects of MPTP on in vivo retinal function (electroretinography, ERG), retinal structure (optical coherence tomography, OCT) and retinal dopaminergic cell number (tyrosine hydroxylase immunohistochemistry, IHC) at two time points (21 and 45 ...
cone opsin genes ranging from a single base change to large deletions have been correlated with loss of vision color. Mutations in the gene encoding the corresponding photoreceptor of retinal rod cells, rhodopsin, are responsible for autosomal dominant and recessive forms of retinitis pigmentosa, a ...
Thus, this point mutant recapitulates certain cone-pigment-like properties in rhodopsin. Residue 122 is located near the β-ionone ring of the chromophore in the helical core of the visual pigment (16), and its substitution has little effect on the interaction of the pigment with other proteins...
Cytosine base editors and adenine base editors (ABEs) can correct point mutations predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial indel formation) and homology-directed repair (which typically leads to low editing efficiency). Here, we show, in adult...
Ectopic expression of NR2E3 in cone precursors and differentiating S-cones of wild-type retina also generated rod-like cells. The dual regulatory function... C Hong,TS Aleman,AV Cideciyan,... - 《Human Molecular Genetics》 被引量: 199发表: 2006年 IL-23 promotes the production of IL-17 ...
These channels are activated by the binding of cyclic nucleotides (cAMP or cGMP)2,3. Native CNG channels are heterotetramers composed of two or three different types of subunits: 3 x CNGA1 and 1 x CNGB1a in rod channels4,5, 2 x CNGA3 and 2 x CNGB3 in cone channels6, 2 x CNG...
A method for obtaining molecules from a substantially intact single cell is disclosed. The method differs from prior methods that obtain a variable fraction of a cell's contents and therefore cannot q