ID3D12ShaderReflectionConstantBuffer * GetConstantBufferByIndex( [in] UINT BufferIndex ); 参数 [in] BufferIndex 类型: UINT 从零开始的索引。 返回值 类型: ID3D12ShaderReflectionConstantBuffer* 指向表示常量缓冲区的 ID3D12ShaderReflectionConstantBuffer 接口的指针。 注解 常量缓冲区向...
Ubiquitin signaling plays a critical role in coordinating protein recruitment during the DNA damage response. Here, we find that the microRNA biogenesis factor DGCR8 promotes tumor resistance to X-ray radiation independently of its Drosha-binding ability. Upon radiation, the kinase ATM and the ...
Erythropoietin (EPO) improves neuronal mitochondrial function and cognition in adults after brain injury and in those afflicted by psychiatric disorders. However, the influence of EPO on mitochondria and cognition during development remains unexplored. W
2.4. RNA extraction, cDNA synthesis and quantitative real-time PCR HT-29 cells were seeded in 6-well plates (5.0 × 105 cells/well) and grown for 36 h, until they reached 60–80% of confluence, and then cells exposed to CFSp and mCM for 4, 8 and 12 h of incubation. In pa...
The reason is the structure of p53 protein folding dynamic change and intrinsically disordered domain [3, 4]. Studies have shown that most p53 mutations have missense mutation preferentially occurred in the DNA binding domain, as a result of single amino acid change at many different positions [...
Moreover, in vitro SV40 DNA replication in normal human cell extracts was inhibited by an excess of either full-length DNA ligase I or the amino-terminal region of the protein, but not by the catalytic domain. This inhibition may be mediated by the interaction of the amino-terminal region ...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we descri
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PW managed the DNA extraction and allocation. JAR performed all molecular experiments including DNA QC and Sanger validation. JLH provided input into the study design and statistical analysis. JRG provided input into the study design as well as the molecular analysis and interpretation. JPH helped ...