Chronic survival and function of adult stem cells from adipose tissue in the ischemic mouse brainJournal of Cerebral Blood Flow & Metabolism stands at the interface between basic and clinical neurovascular research, and features research on experimental, theoretical, and clinical aspects of brain ...
Mesenchymal Stromal CellsAdult Stem CellsMesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to...
This Neurogenesis occurs only in discrete regions of the adult brain: the subventricular zone (SVZ) and the subgranular zone (SGZ). In these areas, there are neural stem cells (NSCs), multipotent and selfrenewing, which are regulated by a number of molecules and signaling pathways that control...
Adult stem cellsEmbryonic stem cellsNanogOct4PluripotencyPseudogenesSomatic tissue-derived stem cellsIn this chapter we will discuss the data published regarding expression of two key ESC transcription factors, Oct4 and Nanog, in adult stem cells. In an introduction, we will discuss what is known.....
Mesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to differentiate into osteoblasts, adipocytes...
Adult stem cells are present in all humans in small numbers. The adult stem cell is one of the classes of cells that we have been able to manipulate quite effectively in the bone marrow transplantarena over the past 30 years. These are stem cells that are largely tissue-specific in their...
The types of stem cells are limited to two –embryonic stem cellsandadult stem cells. Embryonic stem cells are those that form very early in our lives. These come into existence right after fertilization, within a few days of being being a zygote. These cells were mentioned earlier, as toti...
Stem cell transplantation has been considered a promising therapy for retinal degenerative diseases. This study aimed to investigate the therapeutic potential of human periodontal ligament-derived stem cells (hPDLSCs) for intervention in the progress of this degeneration in the Royal College Surgeons (...
We generate patient-derived induced pluripotent stem cells (iPSCs) revealing impaired neural differentiation along with dysregulation of genes essential for neurodevelopment. We identify that OXR1 influences histone arginine methylation by activating protein arginine methyltransferases (PRMTs), suggesting OXR1...
With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting haematopoietic stem cells from metabolic stress. Her