Deep learning prediction of ribosome profiling with Translatomer reveals translational regulation and interprets disease variants Article 23 October 2024 Data availability The datasets are available and can be downloaded at https://codeocean.com/capsule/6711822 (ref. 39). This link includes training...
Code availability Custom codes used to analyze the smFRET data will be provided upon request. References Thal, D. M., Glukhova, A., Sexton, P. M. & Christopoulos, A. Structural insights into G-protein-coupled receptor allostery. Nature 559, 45–53 (2018). Article ADS CAS PubMed Google...
Sections Figures References Abstract Background Results Discussion Conclusions Methods Availability of data and materials Abbreviations References Acknowledgements Funding Author information Ethics declarations Additional information Supplementary Information Rights and permissions About this article AdvertisementEpigenetics...
Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841–2. CAS PubMed PubMed Central Google Scholar Hofmeister RJ, Ribeiro DM, Rubinacci S, Delaneau O. Accurate rare variant phasing of whole-genome and whole-exome sequencing ...
As the progressive decline of motor and cognitive functionalities are hall- marks of neurodegenerative diseases, we reasoned that the longitudinal testing of the same animal may capture the disease progression more faithfully. Furthermore, if the assays are sensitive and the phenotype is strong, the ...
Availability of data and materials Not applicable. Abbreviations ECM: Extracellular matrix EMT: Epithelial-mesenchymal transition CDNA: Complementary DNA ORF: Open reading frame NSCLC: Non-small cell lung cancer PLF: Periostin-like-factor FAK:
Magro F, Fraga S, Ribeiro T, Soares-da-Silva P (2004) Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-γ upon L-DOPA uptake, Acta Physiol Scand. 180:379–386. https://doi.org/10.1111/j.1365-201X.2004.01260.x Manger PR,...
A multi-objective optimization is, in gen- eral, more complex than a single-objective optimization, but the avoidance of multiple simulations runs, no arti - cial x-ups, availability of e cient population-based opti- mization algorithms, and above all, the concept of domi- nance helps to ...
Data availability All datasets generated in this study have been deposited as a super series at the Gene Expression Omnibus (GEO) under accession number GSE216256. Accession codes of the published data in GEO used in this study are as follows: RNA-seq and ATAC-seq of the mouse early embryo...
The BATF and BATF3 gRNA hits in the CRISPRa screen generally colocalized to regions upstream of the promoter and near the summits of accessible chromatin (Fig. 1e,f). scRNA-seq characterization of transcriptional regulators We next characterized the transcriptomic effects of each candidate gene ...