How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA expression, contribute to islet operation. Functional mapping of rodent and human islets containing proportionally more PDX1HIGH and MAFA...
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R. 2010. New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1). Cellular Signalling, 22, 1-8.Yu Z,Jin T.New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-...
Benzyl succinate inhibited the effect of a supramaximal concentration of insulin on 3-O-methylglucose uptake, 2-(methylamino)isobutyric acid uptake and lactate production by the incubated muscle. Furthermore, the inhibitory effect of benzyl succinate on insulin binding in vitro closely correlated with ...
Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides B. Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post- release action of the insulin-like pepti...
These results support that IF1 is a negative regulator of insulin production and secretion via inhibiting mitochondrial mass and respiration in β-cells. Therefore, inhibiting IF1 to improve β-cell function in patients can be a novel therapeutic strategy to treat diabetes. This is a preview of ...
Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant pathways, cell cycle, neuronal protection, a
impairment of insulin gene transcription,and so on.The vicious cycle of elevated glucose further impairs and possibly destroys β-cells,even decrease the insulin production.It seems like tiat early and effective management of hyperglycemia in type 2 diabetes is an important method of preserving ...
Therefore, sweating-induced elimination of xenobiotics is expected to reduce the production of toxic intermediate products and thus prevent oxidative stress. Indeed, our previous study found that the levels of nicotinamide but not its toxic intermediate metabolite N1-methylnicotinamide in the sweat ...
Pectin has a complex structure and diverse biological activities, such as immune regulation, anti-tumor, anti-oxidation, hypoglycemic, and improving gastrointestinal function. Some specific sources of pectin can be used as natural multifunctional food additives, used as gelling agents, thickeners, ...