The fully human anti-CTLA-4 monoclonal antibody is simple in preparation method, can be efficiently expressed in animal cells and is suitable for large-scale production. Besides, the fully human anti-CTLA-4 monoclonal antibody can suppress growth of tumor cells significantly, and has wide ...
human monoclonal antibody CDR: complementarity determining region EC50 : half-maximal effective concentration KD : dissociation constant ka : association rate kd : dissociation rate IFA: immunofluorescence assay GIA: growth inhibition assay ELISA: enzyme-linked immunosorbent assay GOI: gene of...
a fully human monoclonal antibody 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 一个完全的人类单克隆抗体...
which is located outside of the catalytic domain of the protease, we generated a human anti-ADAM10 monoclonal antibody named 1H5. Structural and functional characterization of 1H5 reveals that it binds to the substrate-binding cysteine-rich domain and recognizes an activated ADAM10 conformation presen...
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.: The i
Panitumumab: A Fully Human Monoclonal Antibody with Activity in Metastatic Colorectal Cancer Panitumumab: a fully human monoclonal antibody with activity in metastatic colorectal cancer.Panitumumab: a fully human monoclonal antibody with activity in meta... CE Saadeh,HS Lee - 《Annals of Pharmacotherapy...
Phage display-derived human antibodies in clinical development and therapy mAbs, 8 (2016) 1177-94. Google Scholar [27] R. Rau Adalimumab (a fully human anti-tumour necrosis factor alpha monoclonal antibody) in the treatment of active rheumatoid arthritis: the initial results of five trials Ann....
Here a DDX5-targeting fully human monoclonal autoantibody named after 2F5 was prepared. It is demonstrated that 2F5 selectively inhibited APL cell proliferation without toxicity to normal neutrophil and tissues. Moreover, 2F5 was confirmed to induce G0/G1 phase arrest in APL cells, and promote ...
Panitumumab is the first fully human monoclonal antibody that binds to EGFr. Clinical activity has been demonstrated, most notably in patients with EGFr-positive metastatic colorectal cancer who have failed prior therapy. Phase III study results indicate a 46% reduction in the rate of tumor ...
This article provides a review of human monoclonal antibody tanibirumab (TTAC-0001), which specifically binds VEGFR-2 and is currently being developed in preclinical stage by PharmAbcine (Daejon, Korea). 关键词: Analgesic and Anti-inflammatory Activities Dibenzobarallene Isoindoles Secondary amines ...