Diversity estimates for silent sites are most appropriate for assessing effective population sizes, and the largest difference in such diversity estimates so far published is 7% (in the estimated value of π in Muir et al. (2012)), which is too small to explain the observed difference in ...
Given the large repertoire of γδ TCRs, and the diversity of their ligands, an important consideration was which γδ TCR to investigate. Although Vγ9Vδ2 TCR-expressing T cells are the largest γδ T cell subset in human peripheral blood, much remains unknown about how these receptor...
Functional characterization of XXTs using biochemical and genetic approaches demonstrated that XXT1, XXT2, XXT4, and XXT5 were enzymes that add xylosyl residues to glucan oligosaccharides to synthesize XyG subunits. However, these studies failed to explain the specific role of each of these enzymes...
human genome and can be the source of rearrangements (e.g., Alu/Alu mediated recombination [3]). In addition, long reads may contain multiple breakpoints in one read, which helps to find the order and orientation of the fragments [4]. However, even if all breakpoints are detected, painsta...
Ionising radiation induced DNA damage and subsequent biological responses to it depend on the radiation’s track-structure and its energy loss distribution pattern. To investigate the underlying biological mechanisms involved in such complex system, there is need of predicting biological response by integr...
The suppression of recombination during sex-chromosome evolution is thought to be favoured by linkage between the sex-determining locus and sexually antagonistic loci, and leads to the degeneratio...
In the vast majority of GV oocytes, only one NLB is present, but other GV oocytes contain two or three NLBs, which are similar in structure and immunochemical properties but may differ in size. Two major types of NLBs have been described in fully-grown oocytes of all mammals studied so ...
Answer to: Show an example of the use of palladium catalysis in synthesis. Show the fully labeled catalytic cycle for the example you choose. By...
The biopsies were mechanically dissociated using a TissueLyser (Qiagen, Venlo, The Netherlands), after which DNA was extracted with the NucleoSpin TriPrep purification kit. After the organoids had been cultured for a total duration of six passages (P5) DNA was collected and extracted (n = 6 ...
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