Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a reversible and dynamic modification in posttranscriptional mRNA. Evidences suggest that m6...
A Protocol diagram of the time courses of the Ri. transplantation and behavioral tests. The mice were exposed to CRS and then the behavioral tests were conducted. Half of the CTR and CRS mice were selected for Ri. gavaging, while the other mice were administered equal volumes of sterile ...
We focused on the PPAR signaling pathway based on the results of the enrichment of core targets and pathways, and the schematic diagram of OA in the treatment of obesity by targeting the PPAR signaling pathway is shown in Fig. 2. These findings imply that OA can exhibit anti-obesity ...
Predicted β-sheets in the Ig loop domain, based on the crystal structure of myelin P0 [62], are shown with labeled arrows and correspond to the ribbon diagram included in the lower panel. Lower panel: Proposed three-dimensional structure of the Ig domain of β1 using the crystal structure...
(Top) The diagram shows the results of FLP recombinase-dependent insertion of the FRT targeting vector carrying a cDNA and/or siRNA, into the genome. The promoter driving expression of the lacZ-zeo fusion protein before insertion drives expression of the hygromycin resistance gene after insertion ...
(d). Chord diagram of 22 function-annotated genes. (e). qPCR analysis of the relative mRNA expression levels of genes associated with WAT hydrolysis, synthesis, and adipose neogenesis in CAC and control mice. The findings are presented as the mean ± SEM, with statistical significance ...
Extracellular vesicles (EVs) play an important role in human and bovine milk composition. According to excellent published studies, it also exerts various functions in the gut, bone, or immune system. However, the effects of milk-derived EVs on skeletal
Tree frogs have the remarkable ability to attach to smooth, rough, dry, and wet surfaces using their versatile toe pads. Tree frog attachment involves the secretion of mucus into the pad-substrate gap, requiring adaptations towards mucus drainage and pad lubrication. Here, we present an overview...
Diagram of the improvement in genome assembly completeness. (A) Scaffolding improvement; (B) Scaffolding inconsistencies; (C) Nest assembly errors; (D) Boundary extensions; (E) Gap closure. Full size image The improved genome assembly region features and sequences are shown inSupplementary Note 1...
The trial design is summarized in the trial flow diagram (Figure 1) Figure 1 Trial flow diagram. Full size image Setting & subjects A total of 140 participants with SSc will be recruited from four centres in the UK which specialise in treatment and study of SSc. Sixty participants will be...