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Full size image Enhanced synergistic antitumor immune response with the combination of the HDACi and the IDO1i in PDO models of MSS CRC In the absence of humanized immune cells, we could not clarify the effects of the nanodrugs on immune regulation in the PDX model. Thus, we constructed a...
Full size table Representative stained tumor tissues are presented in Additional file 2: Fig. S1A-D according to the 0-3+ staining intensity classification. CLDN18.2 moderate-to-strong expression was also observed in normal gastric mucosa. We found that CLDN18.2 positivity showed a relatively hig...
Full size image Effect of solubilization agents on the efficacy of dihydroartemisinin treatment in Plasmodium berghei NK65-infected mice Given that DHA is among the anti-malarial drugs recommended for severe malaria treatment and that previous research lacks a standardized protocol for its administration...
Full size image Dil-stained hASCs (2D-cultured, 1 × 106 cells per site; 3D-spheroids from four molds, using aggregated 1 × 106 cells) were implanted in a carrier (0.5% collagen, 100 µL) at a depth of approximately 250 µm to prevent leakage and diffusion of implanted ...
Full size image Effect of curcumin on liver endoplasmic reticulum stress induced by the combination of ochratoxin A and hypoxia stress Similarly, liver ultrastructure revealed that hypoxia exacerbated OTA-induced endoplasmic reticulum swelling. To further investigate the effect of CUR on liver ERS induced...
Full size image Two-step harvesting process In many cases, the use of a combination of two or more harvesting methods can lead to further improvements in harvesting efficiency, production cost, and processing time [74]. A typical combination of harvesting techniques includes a pre-concentration/con...
Full size image To further enhance the extracellular expression level of AmyZ1 by rationally modifying the signal peptide SPNucB, we investigated the relationship between signal peptide sequence features and their mediated extracellular AmyZ1 activity. Therefore, we first randomly selected eight transform...
Full size image SBJDD alleviated colorectal adenoma carcinogenesis and protected the intestinal barrier function in the Apcmin/+ mice model To explore the efficacy of SBJDD in reducing colorectal adenoma formation and carcinogenesis, we utilized the Apcmin/+ mice model and induced colorectal adenoma ...
Full size image Effect of metal-enrichment on microbial communities of N. praecox Next, we compared the microbial communities in N. praecox only, i.e., from metalliferous and non-metalliferous sites. The comparison showed that not only the compartment but also the location is a significant fac...