If a patient had a tibial posterior slope of ≥ 10°, the osteotomy angle was set to 10° in the sagittal plane. Tibial rotational alignment was adjusted to the medial third of the patellar tendon attachment. The anterior and posterior cruciate ligaments were protected during femoral ...
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. Article CAS PubMed Google Scholar Krishnan C...
The reference gene set used was “c5.ontology.all.v2023.1.Hs.symbols.gmt” from the MSigDB database [20]. Statistical significance was determined at an adjusted p-value < 0.05. WGCNA for coexpression network construction and module identification Weighted gene coexpression network analysis (...
In this model, an axial load is applied to the stifle leading to an anterior displacement of the tibia relative to the femur (See Fig.3b) [140,147,148]. The load could be applied in cycles over a period of time or as a one-time single overload if the goal is to cause an ACL r...
Young’s modulus of 17 GPa and 5GPa were set as a mean stiffness for the cortical bone and the cancellous bone, respectively. The modeled tibia consisted of cortical shell with a trabecular core, and the Poisson ratio was 0.3. In specific, before the final fixation, the PL-depression was...
TNF, a key inflammatory mediator in rheumatoid arthritis, inhibits osteogenesis by suppressing the expression of osteogenic genes in MP (Col1, Bglap, Runx2), upregulating Wnt signaling inhibitors in synovial fibroblasts (DKK1, SOST, SFRP) [146, 147], and leading to the generation of BMP3, ...
Heaney RP, Abrams S, Dawson-Hughes B, Looker A, Marcus R, Matkovic V, Weaver C: Peak bone mass. Osteoporos Int. 2000, 11: 985-1009. 10.1007/s001980070020. Article CAS PubMed Google Scholar Raisz LG: Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005...
Osteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confirmed are to the occurrence, development, and invasion of tumors. However, its significance in osteosarcoma remains unclear. In this s
Background In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic efficacy. Here, we set out to explore the relationship between dynamic histone changes...
Main RP, Lynch ME, van der Meulen MC. In vivo tibial stiffness is maintained by whole bone morphology and cross-sectional geometry in growing female mice. J Biomech. 2010;43:2689–94. Article PubMed PubMed Central Google Scholar Lynch ME, et al. Tibial compression is anabolic in the adu...