The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technical challenges in isolat
(5) She had impaired renal function, with elevated blood urea nitrogen (BUN) (17.33 mmol/L) (normal: 1.7–8.3 mmol/L) and urinary protein. We administered measures to ensure fluid intake and without the use of nephrotoxic drugs. (6) She had impaired pancreatic function, with elevated ...
HH-suite is a widely used open source software suite for sensitive sequence similarity searches and protein fold recognition. It is based on pairwise alignment of profile Hidden Markov models (HMMs), which represent multiple sequence alignments of homolo
Only isolated reports showed causal mutations in non-desmosomal genes, such as transmembrane protein 43 (TMEM43), desmin (DES), titin (TTN), Lamin A/C (LMNA), phospholamban (PLN) and αT-catenin (CTNNA3), sometimes with a clinical phenotype similar but not identical to AC, as to be ...
auratais syntenic to the Z chromosome ofM. hyperantus. By matching the protein sequences of theM. auratagenome to eight conserved Z-linked genes (ldh,ftz-f1,ap,cat,ybp,tpi,kettinandtitin2) ofBombyx mori[21], we further confirm that chromosome 17 ofM. auratarepresents the Z chromosome (...
Genes could be comprised in more than one term depending on the function of the encoded protein. The graph shows the most relevant GO terms. The GO term name is reported on the y-axis; the number of enriched DEGs for each term is indicated on the x-axis. GO terms are listed by ...
the manual annotation of 60,770 full-length mouse complementary DNA sequences. These are clustered into 33,409 ‘transcriptional units’, contributing 90.1% of a newly established mouse transcriptome database. Of these transcriptional units, 4,258 are new protein-coding and 11,665 are new non-...
Interestingly, the longest transcript in S. senegalensis v4 and S. solea v1 transcriptomes (Additional file 2,“Longest transcript”) is clearly not an artifact: in both species, it corresponded to a titin-like protein highly similar to a long mRNA (94,446 bp) previously assembled in tilapia...
Mytilisepta virgata is a marine mussel commonly found along the coasts of Japan. Although this species has been the subject of occasional studies concerning its ecological role, growth and reproduction, it has been so far almost completely neglected from
Additionally, we found that 16 protein-coding genes overlapped with the top 30 QTL identified using average distance between deletions. These QTL were largely affected by deleted CNVs. Out of the 16 genes, four (OR10A7, OR2J3, OR6C75, OR6C76) were related to sensory perception as olfactory...