Binary LDL/HDL and TC/HDL ratios showed the strongest association with GDM incidence (OR 1.957 [95%CI 1.258–3.044] and 1.942 [1.243–3.034] respectively). Subgroup analysis showed that an elevated LDL/HDL ratio also increased GDM risk in subgroups with a typically lower prevalence of GDM, ...
However, the NRI of the APRI + metabolomics model indicates a significant improvement in case classification but a negative NRI for non-cases, meaning that some low-risk individuals may be misclassified as high-risk. The results of internal validation metrics are summarized in Supplementary ...
Meaning: This study elucidated the landscape of the relationship between metabolomic/genetic profiles and brain volumes.Introduction The importance of brain structure on behaviors such as personality traits and intelligence and diseases especially psychosocial and neurological disorders has been investigated in...
LDL-C decreased by 23.3% during treatment with N and by 25.6% during treatment with A. The A − N difference, i.e. the mean difference between the within-period changes observed with A and N, was − 2.3% (the minus sign meaning a greater reduction during treatment with A ...
77 articles were accessed for eligibility and full texts were screened. Out of these, 53 were excluded for specific reasons such as wrong study design, duplicate, wrong exposure or outcome, wrong language (meaning different than English), or missing full text. Our final number of included studie...
Clinical studies have suggested that tirzepatide may also possess hepatoprotective effects; however, the molecular mechanisms underlying this association remain unclear. In our study, we performed biochemical analyses of serum and histopathological exami
Arginine treatment reduced TG, FFA, TC and LDL-C in the plasma of HFD-fed male Wistar rats (Fig. 4a, b, c, d). Fig. 4 Arginine (ARG) reduced plasma triglyceride (TG) (A), total cholesterol (TC) (B), free fatty acid (FFA) (C) and low-density lipoprotein-cholesterol (LDL-c)...
To discern the biological meaning associated with the trajectories emphasized by PAGA, an investigation of the spatial organization of clusters on spectral images was done (Fig. 2f). Here we visualize pairwise cluster neighborhood scores ordered by hierarchical clustering of the Z-scores. For instance...
Lipid disorders, also known as dyslipidemias, are conditions involving abnormalities in lipoprotein metabolism, including the overproduction or deficiency of lipoproteins. These disorders may manifest as elevated levels of serum total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides,...
The results revealed that plasma values of hepatic transaminases remained within normal limits, meaning that the selected dose of 60 mg/kg body for MCT injection had no toxic effect on hamster liver. Furthermore, we showed that, 12 weeks after administration MCT induced significant increases in ...