Especially China, which in the past had relatively low rates of dyslipidemia, has seen an increase to more than one-third of the general adult population [1]. Dyslipidemia can be diagnosed according to different lipid parameters: LDL (low-density lipoproteins), HDL (high-density lipoproteins), ...
The evaluated cardiometabolic parameters included fasting blood glucose, triglycerides, total cholesterol, HDL-C, LDL-C, and systolic and diastolic blood pressure measurements. We also assessed the presence of type 2 diabetes mellitus, arterial hypertension, and dyslipidemia. For the data analyses, ...
In type 2 diabetes (T2D), characterized by impaired insulin sensitivity, the lipid phenotype includes hypertriglyceridemia, reduced plasma HDL cholesterol and the conversion of LDL to a more atherogenic lipoprotein, termed small dense LDL [2]. However, the dominant lipid defect in insulin resistance ...
Lipid disorders, also known as dyslipidemias, are conditions involving abnormalities in lipoprotein metabolism, including the overproduction or deficiency of lipoproteins. These disorders may manifest as elevated levels of serum total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides,...
The indirect effect, meaning causative effect of metabolites on glaucoma and AMD through risk factors, could be calculated by the product method (β1*β2). Thus, the proportion of mediation effect could be calculated as ([β1*β2]/β), and the SE and CI could be estimated by the Delta...
(non-HDL cholesterol, LDL, and estimated glomerular filtration rate), we were left with the following list: haemoglobin, haematocrit, red blood cell count, red cell distribution width, monocyte count, albumin, folate, creatinine, blood urea nitrogen, and lymphocyte percentage. Using these biomarkers...
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The low correlation observed between FPedand genomic-based inbreeding estimates suggests that the presence of animals with one unknown parent (sire or dam) in the pedigree does not account for ancient inbreeding. The ROH hotspots surround genes related to reproduction, growth, meat quality, and ada...
Ganoderma lucidum, a medicinal mushroom, belongs to the family Ganodermataceae of the Basidiomycota. The name Ganoderma originates from Greek, meaning shiny, glowing skin (“gános”—shiny, glowing, brightness; and “dérma”—skin). While there are ongoing debates about the classification of the...
2D). A second pathway that our analysis predicted to be dysregulated was the inositol-pathway, as pathway related reporter metabolites were significantly “down”, meaning that the majority of pathway associated genes were down-regulated (Fig. 2B). Fig. 2 Analysis of the plaque-specific GEM ...