(Fig. 4E). Hyperactivated scMEP 3, 7, 10 and 8 states were distinguished by high level of almost all metabolic markers, except for GAPDH, meaning that glycolysis, pentose, TCA, amino acid metabolism as well as FAO were triggered (Fig. 4E). scMEP 4 and 5, which collectively comprised ...
Ganoderma lucidum, a medicinal mushroom, belongs to the family Ganodermataceae of the Basidiomycota. The name Ganoderma originates from Greek, meaning shiny, glowing skin (“gános”—shiny, glowing, brightness; and “dérma”—skin). While there are ongoing debates about the classification of the...
the identification of the characteristic peak components in the characteristic map, meaning the determination of other active components with a single component or the content of the internal standards, and a quality control standard for the absolute or relative quantification of multiple indicators (Fig...
The powerful KEGG modules network allows for inspecting the completeness, meaning the presence of the complete set of enzymes required for a given metabolic reaction and was implemented in ViMO using the R-package MetQy [54]. Alternatively, similar heatmaps can be generated with the KEGGDecoder ...
meaning even small doses can be toxic. The study explored methods for reducing toxicity and detoxifying the herb emphasizing the importance of modern technologies such as propagation techniques, Systematic Evolution of Ligands by Exponential Enrichment (SELEX)-aptamer technology, and Chinmedomics in herba...
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(HPLC-MS). The dataset has a wide variety of small molecules analysed under the same conditions, including metabolites, natural products and drug-like small molecules. It also includes non-retained molecules; these are compounds that are not retained in the column and elute before gradient starts...
‘legere,’ meaning to select or to choose [95]. Initially, it was thought that lectins were limited to plant agglutinins [96]. However, discoveries of lectins from animals and microorganisms including bacteria, algae, and fungi [97,98,99] have led to the understanding that lectins are ...
When we plotted the four groups together (WT / R6/1 ± training), the PCA in three dimensions (3D) completely clustered EVs content per genotype (naïve WT and naïve R6/1) but not by motor learning, meaning that acquiring the task brings closer the protein content of R6/1 EVs...
[103,104]. These variations require that the time of day of sample collection be carefully considered and documented to ensure consistency and reliability of data. Diurnal and circadian rhythms affect the expression of genes and the levels of certain metabolites, meaning that metabolic profiles can ...