Although most cases of ALS are sporadic (sALS) in origin, meaning that there is no family history of the disease, about 10% of patients are familial (fALS). Even though more than 35 genes have been linked with fALS, the most common disease-causing mutations are hexanucleotide (GGGGCC) int...
To understand the biological meaning of DhMRs, we used GREAT with default “Basal plus extension” settings [86]. Enrichment terms with FDR < 0.05 (both region-based binomial and hypergeometric tests) were regarded as statistically significant. For motif scanning on DhMRs and TET1 binding ...
Our pipeline is versatile, meaning that it can be applied to different NBMs that can be ingested accidentally, for environmental or occupational reasons. At the same time, it could provide a huge amount of information on NBMs transformation and acute effects on gastrointestinal tract cells. Further...
A group of neuropeptides may have the same pre-cleavage protein precursor in common, meaning that one gene may code for several peptides with different functions. Although genome information from different species has facilitated prediction of putative precursor cleavage sites and peptide/precursor amino...
The preferential tumor accumulation of iMNP-EGFR particles resulted from the interaction of anchored antibody with tumor receptor as an active targeting and also the enhanced permeability and retention (EPR) effect during particle circulation. The individual images each have diagnostic meaning, and ...
At this time the physiologic meaning of these elevated sFlt-1 levels remains speculative. It might be suggested that sFlt-1 production, by neutralizing VEGF and/or by inactivating membrane-bound Flt-1 and KDR receptors, might play a role in the occurrence of post-CABG complications. ...
We evaluated then the sensitization of rat DRGs by xib1 and xib13. Analysis of the size of cells reveals that mainly small-sized cells are responding to xibalbin toxins meaning that mostly nociceptive neurons are their predominant target (Fig. 8 G, H). As PKA and ERK activity has been ch...
(HBSs), and the connectivity relationship between different dimensions (HBCN). Where the historical building digital twin can be expressed in terms of four model dimensions: geometric (MG), physical (Mp), behavioral (MB) and rule (MR). In particular, the geometric model covers the geometry, ...
Astrocytes (from the Greek word “astro” meaning star) are the most abundant cell type in the central nervous system (CNS) [1, 2]. Astrocytes are important in various physiological processes in the CNS, such as synapse maintenance, blood brain barrier formation and after injury, in the form...
A group of neuropeptides may have the same pre-cleavage protein precursor in common, meaning that one gene may code for several peptides with different functions. Although genome information from different species has facilitated prediction of putative precursor cleavage sites and peptide/precursor amino...