Solid tumors often exhibit high levels of heterogeneity, meaning that different tumor cells within the same patient may not express the same tumor-associated antigen. Therefore, if a single target is recognized by CAR-T cells for treating a solid tumor, the success of the therapy may depend on...
Another study showed that the expression of the SE-associated oncogene FOSL1 was higher in head and neck squamous cell carcinoma (HNSCC) CSCs than in non-CSCs, which may be related to the preservation of CSC-like characteristics, such as self-renewal, tumorigenesis, and metastasis [155]. Supe...
IRE1α/XBP-1 and ATF6 are also up-regulated during hypoxia, although the biological meaning of their activation has been less studied. XBP-1 transcription and splicing are higher in hypoxic tumors [79]. Like PERK, also IRE1α modulates autophagy in response to hypoxia [80], mounting a cyt...
2023). This process consists of a large language model (LLM) which is utilized to extract the semantic meaning of a prompt, which is then encoded into a numerical vector that guides the subsequent image generation (Midjourney, Inc., 2022). The diffusion model itself functions by incrementally...
2002). Recent studies have documented that the role of integrin αvβ3 is complicated, so interpreting imaging data has often become complex in terms of both clinical importance and biological meaning (Robinson and Hodivala-Dilke 2011; Avraamides et al. 2008). Some other reports indicate the ...
as well as model-driven development tools • Easier migration • ST and 3rd parties help customers migrate to these new environments Environment Javascript Python .NET MATLAB/Simulink Meaning High Level Interpreted Language, typically used in HTML, internet and web related design High Level Language...
has shown remarkable potential in immune activation and eradication of tumors. In this review, we delved into the underlying biomechanical mechanisms and the resulting intricate biological meaning in the TME, focusing mainly on the extracellular matrix, the stiffness of cancer cells, and immune synapses...
CircRNAs and piRNAs are both types of non-coding RNAs, meaning they are involved in gene silencing mechanisms, although through different pathways. piRNAs are primarily known for silencing transposable elements in the germ line, while circRNAs can act as microRNA sponges, thereby regulating gene expr...
The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In order to be able to eradicate these CSCs with n
Still, others have reported that more aggressive areas might display increased levels of STn [7]. If this were the case, the FFPE sampling might be an issue. However, this was not the case. In the cases we evaluated the majority were concordant, meaning that if STn was high in the ...