Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst formation throughout the kidney parenchyma. It is caused by mutations in either of two genes, PKD1 and PKD2. Mice that lack functional Pkd1 (Pkd1 -/- ), develop rapidly progres
Upon differentiation, MUTZ-3 can acquire phenotypes comparable to immature DCs or Langerhans-like DCs [8], present antigens through CD1d, MHC class I and II and induce specific T-cell proliferation [9]. Differentiated MUTZ-3 can also display a mature transcriptional and phenotypic profile upon ...
somatostatin receptor 4(SSTR4) andneuropeptide Y receptor Y6(Npy6r). ForNMBR, 35 species displayed a PseudoIndex higher than 2 (Additional file 1: Table S20); however, validated ORF-disrupting mutations were only
We solve the binary class problem ap- proach by employing the "roc_auc_score" built-in function included in the Python Sklearn module [60]. Similar to our prior work [9], we use a one-class-versus-others technique to construct ROC curves with their AUC values for the multi-...
To the best of our knowledge, this study marks the first investigation into the pharmacogenetic association of CYP450 enzymes with antidepressant and antipsychotic treatment concerning drug-induced hepatotoxicity. The exception is agomelatine, where previous literature has explored the influence of genetic ...