While strategies such as chemotherapy and immunotherapy have become the first-line standard therapies for patients with advanced or metastatic cancer, acquired resistance is still inevitable in most cases. The introduction of antibody‒drug conjugates
encoded by resistance (R) genes, which recognize specific pathogen effectors and trigger resistance responses. Disease-related genes, particularly the NLR class of R plant genes, can be triggered by miRNAs to generate phasiRNAs (phased small interfering RNA), which could reduce the transcript levels...
MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes, plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional modulators of gene expression. In invertebrates microRNAs have been implicated as regulators of
Marks R. Narrative review of dance-based exercise and its specific impact on depressive symptoms in older adults. AIMS Medical Science. 2016;3(1):61–76. Article Google Scholar Predovan D, Julien A, Esmail A, Bherer L. Effects of dancing on cognition in healthy older adults: a systema...
Here we show that a single sex-specific protein expressed in adult male mouse urine elicits the highly repeatable inherent attraction of females to spend more time near male than near female urinary scent marks. This involatile protein also stimulates female learning and subsequent selective ...
When reviewing the TCGA slides, we found some obvious artefacts such as pen marks, margin overlap, and defocus. In addition, staining differences were observed between TCGA and the other three cohorts, which also contributed to the performance diversities....
Marks[31] describes the many factors that influence exercise adherence in patients with knee OA as either intrinsic (personal factors like self-efficacy, motivation, age, gender, disease status) or extrinsic (e.g. environmental, social factors or other lifestyle issues). These barriers can vary ...
Acknowledgements We would like to thank Brian Marks and Cristina Mitrea for help and discussions. Review history The review history is available in Additional file 2.Funding We acknowledge the financial support from NIH/NIDDK (1R01DK107666-01), Department of Defence (W81XWH-16-1-0516), and ...
Intel signed a definitive agreement with the U.S. Department of Commerce awarding the company up to $7.86 billion in direct funding under the U.S. CHIPS and Science Act. Intel achieved initial milestones, receiving $1.1 billion in the fourth quarter of 2024 and $1.1 billion in January 2025...
Epigenomics of each variant was annotated by the 15-state ChromHMM model across nine different cell lines in order to capture the significant combinatorial interactions between different chromatin marks in their spatial context (chromatin states). Functional effects included the gene damage index (GDI),...