Schematic diagram of the overall study concept Full size image Western blot (WB), quantitative polymerase chain reaction (qPCR), immunofluorescence staining and ELISA WB experiments were conducted following the previously described procedure. Briefly, for protein extraction, cells were lysed in ice-cold...
Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents an Achille’s heel of these highly tumorigen
Participants were labelled as the proband or another family member and as affected or unaffected within a family. Age at diagnosis was recorded. In addition, probands were labelled as ‘complete’ if a report confirming either a genetic diagnosis or a negative result had been returned to the ...
A Volcano plot showing the dmCpGs with respect to HOMA2-IR (FDR < 0.05 = red, top 10 FDR < 0.05 labelled). B Manhattan plot showing the dmCpGs with respect to HOMA2-IR (FDR < 0.05 = red, top 10 FDR < 0.05 labelled). C Locations of dmCpGs with ...
Emerging evidence has shown that extracellular vesicles (EVs) derived from gut bacteria play a crucial role in microbiota-host interactions. Here, we aimed to evaluate the attenuating effect of EVs derived from a reduced commensal bacterium, F. prausnitz
Social prescribing is gaining traction internationally. It is an approach which seeks to address non-medical and health-related social needs through taking a holistic person-centred and community-based approach. This involves connecting people with and s
Photoacoustic imaging (PAI) is a successful clinical imaging platform for management of cancer and other health conditions that has seen significant progress in the past decade. However, clinical translation of PAI based methods are still under scrutiny
A flow diagram of AMT//T. Step 1, the mitochondria are isolated and the cells are prepared. Distinct markers are labelled in mitochondria and cells for subsequent comparison. Step 2, isolated mitochondria are transferred by different AMT/T methods:aCoculture and noncontact co-culture (transwell)...
Large scale research projects have allowed the team to identify ten key areas in which suicide prevention measure could be improved in hospitals and the community. See the diagram below. You can read more about these on the NCISH website. ...
We aimed to synthesize the qualitative evidence on the impacts of COVID-19-related restricted family presence policies from the perspective of patients, families, and healthcare professionals from neonatal (NICU), pediatric (PICU), or adult ICUs. We sear