Krebs cycle reborn in macrophage immunometabolism. Annu Rev Immunol. 2020;38(1):289–313. Article CAS PubMed Google Scholar Palmieri M, Menga E, Lebrun A, Hooper AC, Butterfield D, Mazzone DA, Castegna M. Blockade of glutamine synthetase enhances inflammatory response in microglial cells. ...
Targeting vulnerabilities of cancer cells by inhibiting key regulators of cell proliferation or survival represents a promising way to overcome resistance to current therapies. In breast cancer (BC), resistance to endocrine therapy results from constitut
TCA cycle has emerged as the central immunometabolic hub of the macrophage [32], the level of which were elevated in M2 cells [33]. Lactate and glucose were decreased in OV-CRNDE-M0 cells compared to M0 cells. Previously study has demonstrated that glucose was decreased and lactate was ...
1E), with a -9.8% relative decrease (95% CI, -15.2% to -4.0%) per 4-year cycle (P for trend = 0.01). Fig. 1 Age-Adjusted Trends in the Prevalence of Hypertension, Elevated BP, Diabetes, Prediabetes, Hyperlipidemia, Obesity, Overweight, Cigarette Use, Inactive Physical Activity,...
Succinate, the intermediates of the mitochondrial pathway known as the Krebs cycle, had extensive evidence for “non-metabolic” signaling functions or metabolic reprogramming leading to altered immune cell and transformed cell function in the initiation of carcinogenesis [55, 56]. Additionally, ...
(France) and acclimated for 1 week before use. Throughout the study, mice were maintained in polysulfone cages in a pathogen-free environment maintained at 22 ± 2 °C under a 12-h light–dark cycle. The experimental design was based on a repeated dose (90-day) oral toxicity OECD ...
calreticulin was shown to be present on the extracellular surface of the oocyte's plasma membrane and in the perivitelline space, and the protein was demonstrated to interact with the cytoskeleton of the oocyte and mediate transmembrane signaling that leads to cell cycle resumption [147]. The disc...
M1 macrophages are often associated with enhanced glycolysis and an impaired tricarboxylic acid cycle, whereas M2 macrophages are correlated with enhanced oxidative phosphorylation and fatty acid oxidation; however, macrophage phenotypes cannot be simply distinguished as M1 or M2, and the metabolic pathways...
Production of energy is a crucial mechanism necessary for the development of cancer cells, therefore it is not surprising to find significant changes in the regulation of the Energy metabolism module between two ovarian cancer subtypes, especially profound in the Krebs cycle, glycolysis and ...
Subsequently, PCA is cleaved through the meta-cleavage pathway (catalyzed by 4,5-dioxygenase) or the ortho-cleavage pathways (catalyzed by 3,4-dioxygenase), which is eventually funneled into the Krebs cycle (Kamimura and Masai 2014; Zhang et al. 2018; Tsagogiannis et al. 2024). Notably, ...