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Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes. It is predominantly found in the astrocytes which are the most abundant subtypes of glial cells in the brain and spinal cord...
In myeloid cells, PSGL-1 is consistently expressed in a functional form on neutrophils, monocytes, and dendritic cells (DCs). PSGL-1 expression on DCs has been shown to induce the formation of tolerogenic DCs. These DCs increase the production of CD4+Foxp3+ Tregs within the thymus and dimini...
WFA is a bioactive compound isolated from the plant Withania somnifera, and when used in combination with cisplatin, it can prevent the increase of Notch 1, Hes1 and Hey1 expression, which presents a more efficacious therapy for ovarian cancer [36]. Hyeok demonstrated that Galectin-3 maintains ...
The goal of this randomized phase II/III study is to formally compare VSP to FHS, while also informing the design for optimal VSP strategies. Methods/design This protocol, consent form, and data collection forms have been approved by the Research Ethics Board (REB) at the University of ...
The resolution of the molecular data differed for each data source. NCIMS and NSWFA contained more detailed molecular level data, reporting the MLVA type in 38.2 and 12.5% of isolates, respectively. Overall, human data had the most extensive representation with the largest number of samples and...
Indeed, as cells differentiate to form specialized structures, the composition of the ECM scaffold similarly differentiates in kind to provide tissue-specific support [8]. The importance of ECM in multicellular organization is evident very early in development, as genes encoding highly conserved ECM ...
several conservationist groups came together to form the World Wildlife Fund (WWF) in 1961. The same year a giant panda arrived at the London Zoo. She seemed like an obvious choice for the conservationist group's logo, and founder Sir Peter Scott set out to create a sketch of the endangere...
Since cellular glycosylation changes can be reflected on released EVs [23,24], quantitative or qualitative changes to EV glycosylation could form the basis for disease diagnosis [12,25,26,27,28]. Various N-glycosylated EV proteins have been proposed as potential cancer biomarkers [29,30,31], ...
(LRP5) signaling by a soluble negative dominant form of LRP5 mutant in OS cells markedly upregulates the expression of E-cadherin, an epithelial marker, and downregulates the expression of N-cadherin, a mesenchymal marker. Inhibition of the Wnt/LRP5 signaling also downregulates the activity of ...