This, in turn, led to activation of ERK1/2, which stabilized the MYC protein. Furthermore, KLF16 interacted with MYC to form nuclear condensates, thereby enhancing MYC’s transcriptional activity. Additionally, MYC transcriptionally upregulated KLF16, creating a positive feedback loop between KLF...
The transplantation of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic intervention for the treatment of neurodevelopmental disorders (NDDs), as well as autism spectrum disorder (ASD). Nevertheless, the efficacy of hADSC...
Whole cell lysates (WCLs) were subjected to Western blot analysis for GRP78 protein level with β-actin serving as loading control. B Same as in (A) except the cells were treated with 35 nM of oleandrin (OLN) alone or in combination with the followings: Tg (300 nM), Tu (1.78 mM)...
Create a .env file in the root directory of your project. Add environment-specific variables on new lines in the form of NAME=VALUE. For example: DB_HOST=localhost DB_USER=root DB_PASS=s1mpl3 process.env now has the keys and values you defined in your .env file. ...
The total percentage of ALP+ cells was determined using a fluorescence microscope. To measure ALP activity, HOB was seeded to 24-well plates and incubated with or without GDPP for 5 days. Then, WCLs were obtained as stated in the Supplementary Materials section “Sodium dodecyl sulfate‒...
Genetic generalized epilepsy (GGE) including childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy (JME), and GGE with tonic–clonic seizures (TCS) (GGE-TCS), is genetically influenced with a two- to four- fold increased risk
Plasmonic visible–near infrared photothermal activation of olefin metathesis enabling photoresponsive materials Introduction As the second-largest petrochemical after ethylene, propylene is widely used in many fields, especially in the form of polypropylene used in the medical field1,2. In industry, propyl...
Phosphorylation at Thr286/287 is an active form of CaMKII [59]. Since our results have identified that TGF-β1 triggered a Ca2+ response in TED-OFs, we wondered whether CaMKII activation played a role in fibrogenesis during TED. As shown in Fig. 6a–d, IHC revealed an increase in ...
WCL has performed the comparative analysis of the 37 bp tandem repeat in teleost mtDNAs and the phylogenetic comparison of the mitogenomes. LO has initiated and led the research project on comparative analysis of Osteoglossids genomes, helped with the experimental design and finalized the manuscript...
This form of cancer is especially prevalent in Taiwan due to the high number of carriers of chronic hepatitis B and is commonly observed among subjects in the 6th decade [3, 4]. Several therapeutic approaches have been developed for the treatment of HCC. Surgical resection is the treatment of...