Predictive, preventive, and personalized medicine will require analyses of potential disease causes on multiple scales ranging from populations to individuals, to their tissues, cells, and molecular species. Since multi-morbidity is common, population-wide analyses are important for characterizing disease c...
MLL1 regulates transcription of critical genes during development. Many proteins have been identified to associate with MLL1 and form a large transcription complex with a molecular mass of ~ 2 million daltons [42]. These proteins play important roles in MLL1-mediated gene regulation. For example...
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WRKY proteins form a substantial TF family known for their conserved WRKY DNA binding domain [23]. They have been implicated in various roles in plant growth and development [24]. Specific WRKY proteins like TTG2 and PH3 have been recognized for their influence on flavonoid biosynthesis by ...
Health education includes consciously constructed opportunities for learning, involving some form of communication, designed to improve health literacy and develop life skills that are conducive to individual and community health [11]. Research has shown that effective health education interventions are based...
This clearly suggests a prioritization of lipid oxidation, i.e., a provision of C in form of acetyl-CoA. In line with this was the up-regulation of the carnitine shuttle, which imports fatty acids to the mitochondrial site of oxidation (L-carnitine dehydratase GJ20083; carnitine/acylcarnitine...
we saw that our result took the form of a weighted average. This is also general; under the Brownian motion model, the average of averages will always be a convex combinationwTX=∑i=1nwiXiof the species dataX1, ...,Xn(see Methods). Thus, in defining our notion of an average, we ha...
of SET-domain protein cofactors. Termed the COMPASS complex (complex of proteins associating with Set1), homologous members of these protein cofactors were later identified in insect and mammalian cells and found to form similar nuclear complexes (COMPASS [KMT2F/G] and COMPASS-related/-like ...
bacteria sample, rRNA and poly(A) depletion performed on total RNA yielded 122 (< 0.1%) of reads mapping to the bacteria,wBm. Using a targeted capture designed forwBm on total RNA, the number ofwBm mapped reads increased to 703,956 (0.9%) [40], which is on average over 850 reads...
HIV infection itself has been shown to increase metabolism of 25(OH) D into the active form, further driving vitamin D deficiency, due to gp120 induced CYP27B1 production [7]. Although some studies have associated VDD with poorer HIV infection outcomes and disease progression, in both cART-...