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Cell reprogramming represents a powerful approach to achieve the conversion cells of one type into cells of another type of interest, which has substantially changed the landscape in the field of developmental biology, regenerative medicine, disease modeling, drug discovery and cancer immunotherapy. Cell...
Furthermore, the emPAI method in its original form [41] as we used it has become somewhat obsolete because of the recent progress in technology. For instance, modern mass spectrometers and the associated software provide high-confidence identifications of much longer peptides than previously possible...
The proposed PMF-GRN framework decouples the generative model from the inference procedure. Instead of requiring a new inference procedure for each generative model, it enables a single inference procedure through (stochastic) gradient descent with the ELBO objective function, across a diverse set of ...
Untargeted metabolomics commonly uses liquid chromatography mass spectrometry to measure abundances of metabolites; subsequent tandem mass spectrometry is used to derive information about individual compounds. One of the bottlenecks in this experimental setup is the interpretation of fragmentation spectra to acc...
in the AMM; the quantities of tokens in a liquidity pool are itsreserves.Footnote3In return, liquidity providers are typically entitled to a share of the fees paid by traders for exchanging tokens. Returns in the form of trading fees provide incentives for agents to act as liquidity providers...
the Zymo clean & concentrator step after adaptor ligation is omitted and the reaction was carried over straight into reverse transcription. For the reverse transcription step to form cDNA, Episcript RT (Lucigen, ERT12910K) was used. Following reverse transcription, excess primer was degraded using ...
We have previously shown that increasing the activity of ASCL1 by ectopic overexpression of a hyper-active form of ASCL1 that cannot be phosphorylated on 5 serine-proline sites (S-A ASCL1) [28] drives differentiation of NB cells [13]. Using NB cells as a broadly permissive neurogenic ...
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of pulses that encodes the information. When an analog electrical signal is digitized, samples of the signal's strength are taken at regular intervals, usually about 8000 samples per second. Each sample is converted into a binary form, a number made up of a series of 1s and 0s. This ...