This may be partly due to the fact that the current series mainly comprised primary GC-like tumors (21/29 cases) which represent a disseminated form of glioma, contributing to a more grim prognosis [12]. Due to the large number of GC presentation in this series, we were not able to ...
This fusion is predicted to result in the upregulation of the MAPK signaling pathway [8]. As the deletion breakpoints in 7q do not involve the CLIP2 or MET genes by CMA (Fig. 2A), the CLIP2::MET fusion likely results from rearrangements in a primarily balanced form. Further RNAseq ...
Nutlin, a selective MDM2 inhibitor, is a negative regulator of the tumour-suppressor gene TP53, triggering apoptosis and cell cycle arrest exclusively in cancer cells retaining the wild-type TP53 form [70]. As depicted in Fig. 2C, seven of the 24 cell lines within this dataset harbour a ...
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which is a key branch of glycolysis, provides the unique sugar donor UDP
Production of mtros ROS are natural byproducts of normal oxygen metabolism that are involved in cell differentiation, cell proliferation, and apoptosis, and ROS are maintained at normal levels in the form of superoxide radical anions and hydrogen peroxide. Homeostasis is associated with the pathologica...
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a unique form of programmed cell death (PCD) distinct from apoptosis, necrosis, and others, has emerged as a key area of interest. However, comprehensive reviews on how natural products influence ferroptosis in respiratory diseases are lacking. This review will explore the therapeutic potential and...
(PBI) contribute to the production of transient macrophage progenitor cells (MPs), with RBI-derived macrophages being the predominant population. In addition, definitive hematopoiesis takes place in the ventral wall of the dorsal aorta (VDA), generating HSPCs that migrate to the kidney marrow. The...
A short form of the General Self-Efficacy Scale (GSE-6): Development, psychometric properties and validity in an intercultural non-clinical sample and a sample of patients at risk for heart failure. Psychosoc Med. 2013;10. https://doi.org/10.3205/psm000091. Jacobsen PB, Andrykowski MA, ...
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, pa