Overactive bladder (OAB) presents a high prevalence of 16–18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been
Vaxxinity, Inc. (Nasdaq: VAXX), a U.S. company pioneering the development of a new class of immunotherapeutic vaccines, today reported financial results for the fourth quarter and full year ended December 31, 2023, and provided a corporate update.
while a substantial body of literature has explored similar topics, South Asia has not been extensively examined in scholarly research, particularly, in the context of a precise and policy-oriented
Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which has been reported to improve cognitive function and memory in patients with dementia. As the underlying mechanism of action of YXT has not been elucidated, we examined the effects of Y
When aggregating cytokine profiles across all three time points the subset of IL-13, 10 and 23 measured at rest were again retained and additional context was recruited in the form IFN-γ at peak effort and IL-15 post-exercise. Used together, these cytokines measured across all three phases ...
We formulate physics-informed neural networks (PINNs) for full-field reconstruction of rotational flow beneath nonlinear periodic water waves using a small
Sequencing was carried out on an Illumina HiSeq 2500 (Illumina, San Diego, CA, USA) in rapid mode with 2 × 250 bp paired-end reads. Sequences were analyzed for single nucleotide-resolved amplicon sequence variants (ASVs) using the DADA2 v1.19.2 package [106] with R v4.0.3 (http:/...
Additional factors that could cause our results to differ materially from those described in the forward-looking statements can be found under the section entitled "Part I—Item 1A. Risk Factors" of our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, which...
Notably, circulating levels of FFAs, including palmitate, are greatly elevated in T2D, and can drive EC dysfunction [15, 19]. Recently, lipid droplets were shown to dynamically form and disassemble in ECs following exposure to FFAs [40]. We transfected HUVEC with control or miR-30e mimic and...
To effectively develop methods to regulate pGC-A, structural information on the full-length form is needed. However, structural data on the transmembrane and intracellular domains are lacking. This work presents expression and optimization using baculovirus, along with the first purification of ...