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A substitution change at position 2080 in VP2 (Ala to Gln) of UKG/34/2001 (PanAsia-1 strain) has been observed from persistently infected cattle[33]. Furthermore, a cell culture adaptation of O/CHA/90 (Cathay topotype) had acquired the ability to grow in WT-CHO cells via the ...
The carboxy terminus of the protein appears to play a role in the assembly of oligomers and therefore the aggregation of NS2 into larger structures [22, 23]. Phosphorylation reduces the affinity of NS2 for ssRNA and appears to increase the number of VIBs that form near the nucleus, in ...