Specificity of UBD and ligases The diversity of ubiquitinylation forms provides a wide range of interactions of tagged proteins with ubiquitin-binding domains, present in many proteins (ubiquitin receptors). Most of them noncovalently bind to the hydrophobic patch around Ile44 of ubiquitin [51]. ...
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This lesson plan was created using three resources: (1) the understanding by design (UBD) method of “Backwards Planning” (beginning with the learning objectives or end result of the lesson), (2) “The Workshop Model” format (“Do Now”, mini-lesson, activity, share, reflection), and ...
Furthermore, we revealed the damaged DNA could activate the NOD-like receptor family pyrin domain containing-3 (NLRP3) inflammasome and subsequently form apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) specks of liver macrophages. Collectively, our results firstly ...
Although a UBD-NZF mutant still interacts with RING1 and RNF2, it prevents formation of Polycomb bodies in osteosarcoma cells, suggesting a dominant negative role in PcG recruitment [25]. Thus, RYBP may play a role in engagement of specific transcription factors, and hence direction of PcG ...
phosphorylated Ub can directly bind to Parkin and is recruited to the surface of mitochondria and phosphorylated by PINK1. PINK1 can phosphorylate Ub in the whole cell and form polyubiquitin chains. While recruiting Parkin, the mitochondrial matrix is also ubiquitinated. Mitochondria labeled with ubiqui...
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similar outcome (FigureS4). We observed no difference in the cytosolic LC3-I level in OPTN(E50K) RGCs (Fig.2J, K), but a significant increase in the lipidated form of LC3-II, an indicator of autophagosome abundance [44], as well as autophagic flux as determined by the ratio of LC3...
First, the participants in the current study were postgraduate adult students who had already graduated and left the university, UBD. In technical and legal terms, the participants were no longer UBD students and therefore not under the jurisdiction of UBD. Based on this argument and the fact ...
Exosomes are extracellular vesicles (EVs) with a bilayer lipid membrane structure, ranging in size from 30 to 150 nm [5]. Exosome formation can be divided into four distinct phases starting with deformation and invagination of the plasma membrane to form early endosomes. Early endosomes mature and...