Pathological Aβ peptides are generated through the cleavage of the amyloid precursor protein (APP) by β- and γ-secretase enzymes [8]. Aβ aggregates over time to form oligomers, protofibrils, and fibrils/plaques. The accumulation of Aβ is a pivotal event in the development of AD, as ...
Our research group has discovered that serious infections such as tuberculosis and COVID-19 leave traces in the form of altered DNA methylation (DNAm). In the PULMO study, we will recruit over 1000 individuals to establish a sample collection comprising specimens obtained from blood, oral swabs,...
Palivizumab guidelines form a precedent for integrating regional risk into policy; they include specifications for infants living in remote northern communities. Our study is the first cost-effectiveness analysis of nirsevimab and RSVpreF to include detailed differentiation of Canadian northern regions and...
Remarkably, SENP3-C532A, the catalytically inactive mutant form of SENP3 [26], failed to regulate LTF level (Fig. 5G), suggesting that the deSUMOylation of LTF protein by SENP3 might be involved in this regulation. Fig. 5 SENP3 de-SUMOylates LTF and blocks its proteasome-dependent ...
With the advent of high throughput assays, the link between tumor heterogeneity and drug resistance came into existence which suggests that under selective drug pressure, few tumor cells divide and form a subpopulation of cells that may achieve features that enable them to become non-responsive to ...
We also computed noise exposure scores by calculating the cumulative noise exposure experience (in dichotomous form) across the three trimesters and limited the score to range from 0 to 3. A higher score reflected higher frequency and longer duration of noise exposure during pregnancy. Measurement ...
Miller (formerly of Simon Fraser University), Judy Mitchell (Positive Living North), Gerardo Mondragon (British Columbia Centre for Excellence), Deborah Money (Faculty of Medicine at UBC), Ken Monteith (COCQ-SIDA), Marvelous Muchenje (Women’s Health in Women’s Hands CHC), Florida Mukanda...
Notably, as a novel form of regulated cell death [10], ferroptosis has been reported to be involved in osteoporosis [11, 12]. Ferroptosis is featured as iron overload and the accumulation of iron-dependent lipid peroxidation. Intracellular iron overload can produce excess amounts of reactive ...
The form and texture of the beads (Ca-alginate) were dependent on both Na-alginate and CaCl2 after NS was employed for encapsulation (Tables 1 and 2). After 6 weeks of culture on MS basal medium without any PGR, we recorded a conversion response of 57.7 ± 1.15% on Na-alginate...
Key to this was of the readiness of members to form close inter-institutional relationships across the institution. An interviewee from one of the villages repeated a common theme saying: “We are a community, so personality, culture and behavior are driven by member commitment to the idea ...