Ferroptosis, a form of regulated cell death (RCD), differs from other classic forms of cell death, such as apoptosis, necrosis, and autophagy, is characterized by unique biochemical features, primarily including iron-dependent lipid peroxidation (LPO) and obvious accumulation of reactive oxygen specie...
In KRAS-mutant cancers, anti-tumor activities of CTLs are regulated by lactylation, which upregulates circATXN7 expression to promote cell death through NF-κB signaling [137]. The immunosuppressive capabilities of tumor-infiltrating myeloid cells and regulatory T (Treg) cells are also regulated ...
for RELB. The major stimulated form of NF-ĸB is its heterodimerization with the p65 subunit and also, association with the p50 or p52 subunit. Notably, the ubiquitous expression of p50 and p65 is observed in different cell types, while RELB expression is limited to a number of specific ...
Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing a critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis and the Janus kinase/signal transd...
Throughput of low conflict TPC-C for timestamp allocation with hardware clock Full size image On one hand, HSTORE greatly benefits from the hardware clock (as expected) achieving peak throughput of \(\sim \)40 M txn/s with an overall speedup over atomic increment of up to 3x. We now al...
Ferroptosis is a form of regulated cell death primarily driven by iron overload and oxidative stress. Elevated ROS levels lead to lipid peroxidation in cellular membranes, a hallmark of this process. The canonical ferroptosis pathway involves the transport of cystine into the cellviathe system xc-...
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic cell death pathway in 2012, ferropt
For all participants with negative results, we conducted follow-ups by phone at the 6th and 12th months using a survey follow-up form. Additionally, we gathered clinical information for participants enrolled at hospitals where electronic health records are available. The cancer surveillance process is...
Ferroptosis, a relatively recent discovery in the realm of cell biology, represents a unique form of regulated cell death. This process hinges on a distinct chemical cascade ignited by the iron-dependent buildup of lipid peroxides. Ferroptosis, in essence, is orchestrated by an intricate interplay...
(NAD) is a cofactor form of the vitamin whereas nicotinic acid dinucleotide is subsequently converted to NAD by NAD synthase (NADSYN1) [54]. NAD is reduced to NADH by oxidative reactions of glycolysis, the TCA cycle, and β-oxidation; and subsequently serves as a redox equivalent carrier ...