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Chemotherapy in the form of neo-adjuvant or adjuvant therapy is the dominant treatment for most of cancers; the resistance directly affects the survival and prognosis of cancer patients [16]. Theoretically, the tumor mass, made of distinct chemo-resistant cell populations has been recognized as an...
of 384 one-d-old male broilers(n=8 replicates/diet)were fed a basal corn-soybean meal diet or the basal diet supplemented with 0.1,0.2,0.3,0.4 or 0.5 mg Se/kg in the form of Na_(2)SeO_(3) for 21 d.Regression analysis was conducted to evaluate the optimal dietary Se levels using...
Ferroptosis, a form of regulated cell death (RCD), differs from other classic forms of cell death, such as apoptosis, necrosis, and autophagy, is characterized by unique biochemical features, primarily including iron-dependent lipid peroxidation (LPO) and obvious accumulation of reactive oxygen specie...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
the evidence suggests that termination of pregnancy might be a necessary form of management to prevent maternal morbidity [105,106]. Regarding to maternal-neonatal outcomes, clinicians need to fully compare the risk of elective delivery against expectant management of severe PE less than 34 weeks of...
[140]. Ginsenoside Rh2 induces increased ROS levels and activates the NF-κB pathway in colorectal cancer cells; it also induces paraptosis, a form of PCD that is characterized by cytoplasmic vacuolization [141].Piper longumL. is a naturally existing edible and medicinal plant that grows as a...
In this context, natural killer (NK) cells have attracted considerable attention as a potential form of ACT, largely due to their antigen-independent, robust cytolytic activity against cells that display specific surface features (Box 1) [6]. Abundant preclinical data indicate that NK cells not ...
and il-18. another important function of inflammasomes is the induction of caspase-1 dependent pyroptosis which is a form of cell death characterized by both apoptosis and necrosis. this results in release of il-1β and il-18 as well as other inflammatory mediators such as il-1α and hmgb1...
To confirm that the deletions observed in the present cases were not non-pathogenic genomic copy number variations (CNV), a cohort of 100 healthy normal subjects (50 men and 50 women) was tested. All volunteers were informed about the study and signed a consent form approved by the local ...