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Transient receptor potential (TRP) proteins form a large gene family of ion channels characterized by distinct activation mechanisms and biophysical properties. By sequence homology, members of the family fall into six subfamilies (TRPC, TRPV, TRPM, TRPML, TRPP, and TRPA). There is mounting evid...
The aroGfbr overexpression under the control of Pcore-trc effectively enhanced L-Phe production. The GAP strain had the highest L-Phe production at 1.02 ± 0.03 g/L. Therefore, it was used as a chassis strain to construct the biosynthetic pathway of benzyl acetate. Benzyl alcohol ...
TF is a transmembrane glycoprotein known as thromboplastin that is present on the surface of many different types of cells [4,5,6], including cancer cells [2, 3, 7, 8]. TF plays a critical role in the coagulation cascade, the process by which blood clots form in order to stop ...
Our study will be the first to examine the outcomes of treatment specifically in the severe early onset form of ICP, comparing “standard” UDCA therapy with rifampicin, and so be able to provide for the first-time high-quality evidence for use of rifampicin in severe ICP. ...
To test if higher expression levels of HMGR could improve isopentenol production, we built a set of strains in which the isopentenol production pathway was chromosomally integrated at the idsA locus. The ∆idsA strains form white colonies instead of the wild-type yellow color [35] facilitating...
pivotal role in disrupting normal renal structures and the loss of renal function. Ferroptosis is a recently discovered iron-dependent form of cell death characterized by lipid peroxide accumulation. Ferroptosis has emerged as a potential key player in various diseases and the initiation of organ ...
TNBC is a form of breast cancer that exhibits special molecular and biological characteristics, which is often associated with young age at onset, a high malignant biological behavior, easy metastasis and poor prognosis, approximately 10–20% of all breast cancer patients are affected by this ...
What needs to happen to get it merged into the main codebase so that between Hyper and Atom my development environment can reach its final form? [windowsetFrame:fullscreenFramedisplay: //Fullscreen windows can't be resized, minimized, etc. ...
Ubiquitination in autophagy. The initiation of autophagy is stimulated by various factors or can be regulated by other upstream molecules, such as AMPK, mTOR, p53, etc. Subsequently, cup-shaped membrane structures elongate, bend, and eventually close through membrane fission to form double-membrane ...