The lack of a significative modulation in the upper alpha band (i.e., alpha3) following MBI aligns with the idea that alpha3 is selectively responsive to semantic memory demands [31] and that mindfulness practice may not have a specific impact on this form of memory [70]. In the ...
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i Electron microscopy image of the form of mitochondria in neutrophils. j Intracellular iron colorimetric assay showing the concentration of total Fe in neutrophils. k LPO assay showing the concentration of LPO in neutrophils from bone marrow. l Immunostaining of MBP (green) and nuclei (DAPI, ...
Maintenance of physical function, mobility, and independent living are important goals for older adults. However, concerns about falling (CaF) play a central role in the vicious cycle of CaF, inflammation, loss of muscle mass, and decreasing physical function ultimately resulting in negative health ...
Aβ is generated by the normal cleavage of the amyloid-beta precursor protein (APP), which then can oligomerize and form extracellular deposits [9, 10]. Some mutations in the APP gene cause a familial early-onset form of AD through modification of APP cleavage resulting in an increase in A...
They were told that their cognitive and functional abilities would be assessed, that it was possible to detect impairments of which they were not aware, that should this happen, their GPs would be contacted with their consent. After they read the PIS, they signed a consent form prior to ...
The mixture was vortexed for 30 s, and then kept still at room temperature for 30 min to form a TPP-PEG-PAMAM-malic acid polymer [38, 39]. Hereinafter referred to as TPP@PAMAM@MA. DMSO-d was used as solvent, TPP@PAMAM@MA was identified by 1HNMR, particle size distribution, zeta ...
Thus, it is likely that these increases in soluble α-syn (even in the monomeric form) in the brains of AD patients are the source of an important correlate of decreased cognitive function in AD. As DLB patients also have neuronal damage, it may seem surprising that there is no α-syn ...
Using in vitro and in vivo experiments, we found that circ467 binds to eIF4A3 and suppresses its nuclear translocation; moreover, circ467 can form a complex with eIF4A3 and c-Myc mRNA in the cytoplasm, which promotes c-Myc translation and activates c-Myc signaling. This leads to the up...
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