In addition to the high immune heterogeneity of tumor cells, the heterogeneity of other cell types further increases the complexity of tumor tissue. These different types of cells form a complex interaction network through ligand-receptor interaction, paracrine, autocrine, and other intercellular ...
Despite the increased PD1 levels, an improved PD1+CD28+ T-cell polyfunctionality was observed with the transition from periphery to tumor site, associated with lack of TIGIT, TIM-3 and LAG-3, but not with Ag-experienced-marker CD11a. Differently from CD28+ T cells, the increased PD1 levels...
Similarly, B cells from germinal centers (GC) show increased glycolysis and high mitochondrial content, and LDHA-deleted naïve B cells had a severe defect in their ability to form GCs and mount antibody responses [50]. Again, OXPHOS was shown to fuel the metabolic requirements of high-...
The resulting extract was then derivatized to form pentafluorobenzyl esters and injected into a capillary gas chromatograph column to resolve individual fatty acids from other matrix constituents. FFAs were expressed as a % of total fatty acids (FFAs/the sum of measured fatty acids). Values of ...
The membrane segment mainly consists of the Wnt receptor FZD and LRP5/6. The cytoplasmic segment primarily encompasses β-catenin, DVL, GSK3β, AXIN, APC, and CK1. The nuclear segment mainly involves β-catenin translocated into the nucleus, TCF/LEF family members, and downstream target ...
If the data is kept in the encrypted form in cloud servers, then researchers, who are approved for access, need to download large quantities of data locally and decrypt them to perform analysis, which defeats the purpose of outsourcing the storage to the cloud. This situation creates additional...
In addition, we observed that the large percent T > G variants with VAF < 0.01, which recently occurred and not yet accumulated in cells, were associated with ESCC prognosis. This may portray a form of mtDNA instability, presented as a large number of low-frequent T > G ...
The association between gene polymorphism of TCF7L2 and type 2 diabetes in Chinese Han population: a meta-analysis. PLoS ONE. 2013;8(3):e59495. Article CAS PubMed PubMed Central Google Scholar Yan Y, North KE, Ballantyne CM, Brancati FL, Chambless LE, Franceschini N, et al. ...
CRISPR system into human primary T cells in three different forms: (i) Viral delivery of CRISPR vectors, such as LV or adeno-associated virus (AAV), (ii) Cas9 mRNA combined with synthetic guide RNA, (iii) Binding of Cas9 protein and synthetic guide RNA to form RNP complex [10, 11] (...
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence rates and severity of progression. The cellular and molecular mechanisms underlying this clinical phenomenon remain elusive and ill-defined. ...