Chemotherapy combined with or without targeted therapy is the fundamental treatment for metastatic colorectal cancer (mCRC). Due to the adverse effects of chemotherapeutic drugs and the biological characteristics of the tumor cells, it is difficult to ma
3’ splice sites (3’ ss), branch point sites (BPS), and (BPS), and polypyrimidine channels (PPT). U1 snRNP recognized 5’ss, and SF1 bound BPS, U2AF2 and U2AF1, PPT, and 3’ss to form the E complex, respectively. U2 snRNP replaces SF1 and binds to BPS ...
In addition to the high immune heterogeneity of tumor cells, the heterogeneity of other cell types further increases the complexity of tumor tissue. These different types of cells form a complex interaction network through ligand-receptor interaction, paracrine, autocrine, and other intercellular ...
Some particular antigens expressed on plasma cells can efficiently recruit specific CAR-Ts for MM. BCMA (CD269/TNFRSF17), with near-universal expression in MM, is the most intensively studied target for MM CAR T-cell treatments. One of the barriers to the success of CAR-T therapy is anti...
β-Catenin and transcriptional coactivators such as T cell factor (TCF) form complexes that contribute to the transcription of Wnt-responsive genes, inducing cellular responses [40]. Wnt/β-catenin has also been associated with the progression and development of cancer, and it has been identified ...
PBAF is the canonical SWI/SNF form, inducing TCF+ progenitor T cells to a more exhausted state. The loss of PBAF augments responses to PD1 pathway blockade and improves tumor control in combination with immunotherapy [62]. E3 ubiquitin ligase Cblb is upregulated in exhausted CD8+T cells. ...
In addition, many studies have attempted to modify engineered CAR T-cells to induce endogenous antitumor immunity and thus reshape the TME. One study designed a novel CAR T-cell (RN7SL1 CAR T-cell) that secreted non-coding RNA RN7SL1 in the form of extracellular vesicles (EVs), which wou...
In addition, we observed that the large percent T > G variants with VAF < 0.01, which recently occurred and not yet accumulated in cells, were associated with ESCC prognosis. This may portray a form of mtDNA instability, presented as a large number of low-frequent T > G ...
252 co-upregulated genes were used to screen key genes to form a gene panel Full size image Screening key radiation-resistance genes related to clinical outcomes in colorectal cancer To investigate the key genes that had the greatest impact on the prognosis of colorectal cancer patients who ...
CRISPR system into human primary T cells in three different forms: (i) Viral delivery of CRISPR vectors, such as LV or adeno-associated virus (AAV), (ii) Cas9 mRNA combined with synthetic guide RNA, (iii) Binding of Cas9 protein and synthetic guide RNA to form RNP complex [10, 11] (...