Systems biology boosts the understanding of citric acid metabolic regulation in A. niger Citric acid is the first intermediate of the TCA cycle, and is synthesized by the condensation of acetyl-coenzyme A (acetyl-CoA) and oxaloacetate moiety [1]. Acetyl-CoA is converted from pyruvate with 1 ...
The increase in PHV production could also be a result of increased generation of reducing equivalents by PAO either through the full or partial TCA cycle, since PHB is predicted to be the only PHA fraction produced from acetate if reducing power is generated solely through glycolysis....
The sub-network is obtained by leaving the default parameters and setting a limit of nlimit = 150 nodes. Several “TCA cycle”-related entities are highlighted, also found by the authors and by previous work [22]. It also mentions “sphingosine degradation”, closely related to the reported ...
but the expression patterns of the genes encoding these enzymes in a multicellular organism have not yet been systematically examined. Genes encoding glycolytic and TCA cycle enzymes are a particularly attractive target for a systematic analysis of expression patterns because their products form pathways....
As regards the TCA cycle, Icdh was up-regulated in the Δpta mutant while the first enzyme of the glyoxylate shunt (Icl) was down-regulated in the deleted strain in both phases. Taken together, these changes clearly reflect a more active glycolysis and TCA cycle in the mutant strain as a...
More than 15.2% of the proteins were directly involved in energy metabolism, including parts of the oxidative phosphorylation machinery (OXPHOS), members of the tricarboxylic acid cycle (TCA), and the pyruvate dehydrogenase complex (PDH). Among underrepresented categories were the following: (i) ...
The tricarboxylic acid cycle (TCA) of D. hafniense DCB-2 and Y51 appears incomplete since they lack the gene coding for 2-oxoglutarate dehydrogenase, and the cycle lacks the anaplerotic glyoxylate bypass (Figure 2). In most autotrophic bacteria and anaerobic Archaea, the TCA cycle operates in...
A lower cell-type specific abundance of glutamine synthetase (GlnA/GS) was also evident in the newly formed heterocysts while it showed a higher abundance in heterocysts from steady-state diazotrophic cultures. Proteins involved in the TCA cycle (DhsB; GltA, Icd and AcoB) and the OPP ...
of nucleotides or is converted to various C3–C7 sugars through the transketolase/transaldolase reaction in the non-oxidative part of the PPP. Pyruvate, the end product of glycolysis, usually gets transported into the mitochondria, converted to acetyl-CoA and channeled into the TCA cycle for oxidat...
form of replenishment. For example, a variety of amino acids such as aspartic acid, arginine, glutamic acid, glutamine, histidine, isoleucine, methionine, phenylalanine, proline, tyrosine, threonine, valine etc. can complement the eight intermediate metabolites in the tricarboxylic acid cycle (TCA)....