Danger signals activate NOD-like receptors, which can form multi-protein complexes or inflammasomes, promote the cleavage of pro-caspase 1 into active caspase-1, and subsequently activate proinflammatory cytokines, including IL-18 and IL-1β [61]. In experimental models, inflammasomes and ...
Integration of peptidomimetic and nanotechnology The highly effective nature of nanoparticles (NPs) in overriding the body’s natural defense system and its vascular barriers has led to a wide range of applications in medicine and pharmacy. A few of the applications are drug delivery, vaccine, biolo...
Since no vaccine was available then, WHO introduced the COVID-19 preventative measures to reduce the chances of virus transmission. The guideline for individual preventative included practising hand and respiratory hygiene by regularly cleaning hands with soap and water or alcohol-based sanitisers, wea...
The U.S. government has agreed to acquire 100 million doses of each vaccine with the option to purchase many more. It’s not clear, however, how quickly the companies can manufacture enough to vaccinate all 330 million Americans. Pfizer and BioNTech hope to manufacture up to 1.3 billion dos...
Progress towards the development of a NEAT vaccine for anthrax II: immunogen specificity and alum effectiveness in an inhalational model. Infect Immun. 2020;88:e00082-20. doi: 10.1128/IAI.00082-20. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new...
Messenger RNA (mRNA) vaccines have emerged as a transformative platform in modern vaccinology. mRNA vaccine is a powerful alternative to traditional vaccines due to their high potency, safety, and efficacy, coupled with the ability for rapid clinical dev
There have been intense efforts to develop an effective vaccine and cure for HIV-1; in fact, over the past decade, several PLWH appear to have been cured [4]. Some of these individuals received transplants with donor CCR5Δ32 material, rendering their cells resistant to R5 HIV-1 infection...
Particularly for the elderly, the differences between individuals in vaccine utilization are also explained by country-level factors, such as the type of healthcare system adopted in each country, public funding, personal health expenditure burden, or the availability of generalist practitioners. ...
Among these, TGF-β1 is the predominant isoform and the most relevant member of the family in terms of immune regulation. All three forms are synthesized as prohormones and exist in a latent form (L-TGF- βs) by noncovalent association with the latency-associated peptide (LAP) and must ...
vaccine candidates for poultry. Work form the Szymanski group has shown that a diphtheria toxin fused to aC. jejunipeptide containing nine acceptor sequons modified withC. jejuniheptasaccharide significantly reducedCampylobactercolonisation of the chicken gut [27]. A prior study from our group ...