The advancement of single-cell 3D histology has been driven by two main catalysts: spatial omics and imaging techniques. Spatial omics enhance our understanding of intracellular processes by providing detailed insights into the molecular characteristics of cells within their native 3D context. This approa...
The ATP-binding cassette A1 (ABCA1), a transmembrane protein, plays a crucial role in transporting intracellular free cholesterol to lipidate ApoE and form HDL-like particles for cholesterol transport in the brain [25–28]. Recycling of ABCA1 to the plasma membrane is critical for cholesterol ...
Nevertheless, we may lack power to detect a significant interaction due to a lower number of patients developing the latter conditions. This may be especially so for CHP, since CHP is a form of RHP, and the point estimate of the mean effect of Early PN in CHP patients may suggest ...
For instance, there is a long-standing history of terrier and mastiff-type breeds being crossed in the mid-1800s to form multiple bull terrier- and terrier-like breeds such as the Staffordshire Bull Terrier and the Boston Terrier (see the Bull Terrier subclade). There is also excessive ...
The tissue was obtained in 1980 based on a pathology consent form and distributed to us under a current IRB which explicitly allows distribution of materials. Consent for publication All authors approved the final manuscript before submission. Competing interest The authors declare no competing ...
2D). The PAGA plot depicts that these domains form an approximately linear trajectory (Fig. 2E). We also conducted domain-specific expression analysis on the structures identified by SR-DGN. Figure 2F displays the top three domain-specific genes. We found that the expression of these genes ...
Language has the power to shape cognition, behavior, and even the form and function of the brain. Technological and scientific developments have recently yielded an increasingly diverse set of tools with which to study the way language changes neural str
Methodologically, it is always easier to study canonical Islam, whether in the form of piety movements, or in the analysis of fatwas, for instance. More recently anthropology has tried to capture ‘everyday Islam’, an intervention that undeniably expanded the textual focus; but even then, ...
Secondly, the sublimation of tungsten wire caused by high temperature will cause tungsten particles to be emitted into the vacuum area to form impurities [30, 33]. The class cracks caused by high temperatures during exposure may allow air to enter the vacuum tube [30, 32]. However, the X-...
Bayesian nonparametric inferential procedures based on Markov chain Monte Carlo marginal methods typically yield point estimates in the form of posterior expectations. Though very useful and easy to implement in a variety of statistical problems, these methods may suffer from some limitations if used to...