to the greatest degree or extent; completely or entirely; (`full' in this sense is used as a combining form); "fully grown"; "he didn't fully understand"; "knew full well"; "full-grown"; "full-fledged" full moon · full-of-the-moon · full phase of the moon the time when th...
Sialofucosylated structures, particularly Sialyl Lewis a/x-enriched MM cell population, can bind to platelets through P-selectin and protect myeloma cells from NK cell-mediated killing [53]. Thus, disruption of platelet–MM cell interaction using P-selectin-blocking antibodies can be exploited as ...
Post-translational modifications unrelated to glycanation, but associated with defined sialo-fucosylations, create a selectin-binding glycoform of CD44 denoted HCELL (“Hematopoietic Cell E-selectin/L-selectin Ligand”). This glycosylation variant is known to be abundantly expressed on hematopoietic stem...
The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations. This study employed a det
While there was a marked increase in nuclear-related statements, the pattern and form were not new. Furthermore, despite the flaunting, exercises and movements of weapons were largely routine and did not appear to signal potential early and limited nuclear escalation. Ultimately, the way in which...
(APP) processing,PAWRandPSEN2, the first involved in the progression of age-related diseases, and the second causal of an inherited form of Alzheimer’s disease.BDNF, whose expression is reduced in Alzheimer’s, Parkinson’s, and Huntington’s disease patients, was also downregulated in this ...
a) Gingivitis (the mildest form of the disease); the gums become red, swollen and bleed easily. There is usually little or no discomfort at this stage, but the presence of bleeding indicates that the epithelial insertion is already compromised, what creates an interface between the internal an...
Short and readable descriptions of molecular graphs are linear notations. A clear example is the broadly used Simplified Molecular Input Line System (SMILES), which captures a molecules’ structure in the form of an unambiguous text string using alphanumeric characters. They allow the efficient storag...
The mutation causing the most common form of facioscapulohumeral muscular dystrophy (FSHD) was identified over 20 years ago, yet for many of the ensuing years there was little or no consensus in the scientific community regarding the molecular pathophysiology of the disease. Unlike other disease-...
Amyotrophic lateral sclerosis (ALS) is a term used to cover the spectrum of neurodegenerative syndromes characterised by progressive degeneration of motor neurones. However, it is also the term used in modern clinical practice to indicate the commonest form of the disease, Classical (Charcot's) AL...