Cells were exposed to the appropriate treatment and cultured for 10–14 days to form colonies. The debris was washed twice with 1 ml of PBS, and the cells fixed with 4% paraformaldehyde in PBS and stained with 0.05% crystal violet for counting. Three replicates were used and data are ...
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Osteoarthritis (OA) is the most common form of arthritis and is associated with pain and loss of joint function. It imposes a huge burden on individuals and the social economy [1]. OA is becoming more common as the population ages and obesity increases [2]. Although the cause of OA can ...
Typical two-dimensional (2D) culture models of skeletal muscle-derived cells cannot fully recapitulate the organization and function of living muscle tissues, restricting their usefulness in in-depth physiological studies. The development of functional 3
(0N4R isoform) was observed to reduce tau filament formation in a cell-free system [88]. However, another study reported that clusterin facilitates tau seeding (2N4R isoform) by stabilising oligomeric tau seeds in a cell-based seeding assay [89]. An intracellular form of clusterin was found...
Mitie is recognised as a leader in ESG among global industry peers. These initiatives form a key part of how we do business, ensuring we grow sustainably and responsibly. Our leading credentials also enable us to work with our customers to realise their own sustainability and Net Zero ambitions...
Scars are a consequence of cutaneous wound healing that can be both unsightly and detrimental to the function of the tissue. Scar tissue is generated by excessive deposition of extracellular matrix tissue by wound healing fibroblasts and myofibroblasts,
The range of sol-BG was found to be between 96 pg/mL to 2600 pg/mL (Suppl. Figure6A). The average concentration of sol-BG across all repositories was 993 pg/mL, with a median of 915 pg/mL (Suppl. Figure6A), suggesting that potential differences in banking the fluid and age of flu...
An ageing population that has a disproportionate number of individuals with one or more co-morbidities will place significant demands on the health system, the first effects of which will likely be seen in the near future as the current baby-boomer generation (born 1946–1964) reaches ages ...
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