2D representations are produced in the form of SVG images, whereas 3D representations are returned as HTML files containing embedded JSMol objects [57, 58]. Through REST API calls, the tools and ocsr modules offer convenient access to the underlying functionalities of the integrated tools. For ...
This, in turn, led to activation of ERK1/2, which stabilized the MYC protein. Furthermore, KLF16 interacted with MYC to form nuclear condensates, thereby enhancing MYC’s transcriptional activity. Additionally, MYC transcriptionally upregulated KLF16, creating a positive feedback loop between KLF...
Ferroptosis, a form of regulated cell death (RCD), differs from other classic forms of cell death, such as apoptosis, necrosis, and autophagy, is characterized by unique biochemical features, primarily including iron-dependent lipid peroxidation (LPO) and obvious accumulation of reactive oxygen specie...
SFB contributed on the conception, data curation, and critical review of the manuscript. SCM contributed on the conception, data curation, critical review and manuscript revision. Corresponding authors Correspondence to Sammy Ferri-Borgogno or Samuel C. Mok....
Colorectal cancer ranks as the third most prevalent form of cancer in the population and is well recognized as a significant global public health concern. Colorectal cancer has the potential to metastasize from the colon’s surface to the colon tissue and other organs such as the liver, prostate...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
The association between the genotype at the non-recombining region and the social form is imperfect in P. californicus. Pleometrotic queens were predominantly homozygous (85%) for a single haplotype (Sp), while most haplometrotic queens (93%) carried at least one copy of the Sh haplotype. ...
Segmented filamentous bacteria (SFB), which play a major role in the maturation of the intestinal immune system, promote the differentiation of Th17 CD4 T cells under the effect of IL-17, and induce Th17 cells to prevent the intestinal colonization of pathogens [39]. Under inflammatory ...
1Explanation of PMI's use of non-GAAP measures cited in this document and reconciliations to the most directly comparable U.S. GAAP measures can be found in the “Non-GAAP Measures, Glossary and Explanatory Notes” section of this release, in Exhibit 99.2 to the company's Form 8-K dated...
play out the last year of his contract it’d pay to ensure there’s a succession plan in place. Landon Dickerson suffered a torn ACL in December and may need time to round into form, but he’s a battle tested pivot with the versatility to serve as a utility lineman early in his ...