E means the chemical bond of the drug molecule, i.e., the edge in the two-dimensional structure graph, and it usually appears in the form of an adjacent matrix. In the process, two tools were mainly used, namely RDKit and DeepChem [27]. Each atom in the molecular graph is expressed...
Datafication is also a form of world-making that depends on two onto-epistemic turns: decisions about what information is (and is not) valuable enough to collect as data and the requirement to reconceptualize social and ecological relations as data. Datafication thus serves to consolidate the ...
As a final test, however, an untagged form of human importin beta was cloned and used in a rescue experiment. We found that untagged human importin beta blocked the ability of nuclear pores to form when BAPTA-arrested nuclei were diluted into fresh cytosol (Figure 4B, +h-β). However, no...
Plant A/T-rich protein and zinc-binding protein (PLATZ) transcription factors are pivotal regulators in various aspects of plant biology, including growth, development, and responses to environmental stresses. While PLATZ genes have been extensively stud
Bacterial taxonomy and phylogeny based on rrs (16S rDNA) sequencing is being vigorously pursued. In fact, it has been stated that novel biological findings are driven by comparison and integration of massive data sets. In spite of a large reservoir of rr
This hypothesis is supported by the findings of the MCC and MJ network analysis, showing that isolates form the eastern part of the OWH (Fig. 3, green circle) were more related to isolates from central Bohemia (Czech Republic), whereas OWH isolates collected closer to the Rhine plain (Fig....
The results of this study will be disclosed unreservedly in the form of scientific publications. Participants are notified of study proceedings through regular newsletters. When necessary the protocol can be modified or additions can be made. This can be done through amendments, which need approval ...
The existing methods of fold recognition can broadly be divided into two types. In the first, the information is represented in linear form, called a profile, which is based on empirically derived scores for the expected occurrence of residues in a particular structure [6–13]. This type of ...
They performed an in silico analysis by using MEME (Motif-based sequence analysis tools; http://meme.sdsc.edu/meme4_1_1/intro.html) of the possible presence of a CDRE-like consensus motif in the promoter regions of 25 AnCrzA-dependent genes. By analyzing their promoter regions, 5'-G[T...
The C-terminal protein-binding domains of BiPs has five highly conserved amino acid residues (Figure 1), which form a five-residue substrate core and facilitate hydrogen-bonding with the peptide-substrate backbones. The αβ motif (Domain 5) located in the C-terminal protein-binding domain main...