Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which has been reported to improve cognitive function and memory in patients with dementia. As the underlying mechanism of action of YXT has not been elucidated, we examined the effects of Y
To effectively develop methods to regulate pGC-A, structural information on the full-length form is needed. However, structural data on the transmembrane and intracellular domains are lacking. This work presents expression and optimization using baculovirus, along with the first purification of ...
Jin-Gui-Shen-Qi Wan (JGSQ) has been used in China for thousands of years to treat various ailments, including frequent urination, blurred vision, and soreness in the waist and knees. It has traditional therapeutic advantages in improving eye diseases. Cl
As in eukaryotes, precursor transfer RNAs in Archaea often contain introns that are removed in tRNA maturation. Two unrelated archaeal species display unique pre-tRNA processing complexity in the form of split tRNA genes, in which two to three segments of tRNAs are transcribed from different loci,...
Superoxide dismutases (SODs) are a key antioxidant enzyme family, which have been implicated in protecting plants against the toxic effects of reactive oxygen species. Despite current studies have shown that the gene family are involved in plant growth a
Recently, the increased demand of energy has strongly stimulated the research on the conversion of lignocellulosic biomass into reducing sugars for the subsequent production, and β-glucosidases have been the focus because of their important roles in a variety fundamental biological processes and the sy...
(2) researchers can mutate the degrons or block E3-degron interactions to upregulate the expression of tumor suppressors [12], which may be a feasible way to treat cancer; and (3) chemists can design PROTAC drugs to link a substrate with a predicted binding E3 to form double bonds ...
These three edges form the set R of potentially removable edges. According to the rules, TRANSWESD removes first edge A → C as it has the largest weight (lowest confidence). In the second iteration, A → B can be safely removed. Now the algorithm has to stop even though the...
These core structures can undergo further extension and branching to form more highly complex O-glycans [13]. Mucin type O-linked glycans are synthesized in the Golgi apparatus [14] in a stepwise and consensus motif-independent manner. A family of UDP-GalNAc polypeptide:N-acetyl-α-galactos...
anti-GBM activity; however, infusion toxicities and difficulty in penetration through the blood−brain barrier (BBB) are current challenges that limit the systemic treatment of GBM with an IgG1 form of anti-CD47 antibody. In this work, we generate an oHSV carrying a transgene encoding a ...