The increasing development of Internet of Things technology and the widespread use of smart devices (SDs) are making resource competition more and more intense [19] while also facing security threats. Resource
The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β (gp130) on the cell membrane. A recombinant soluble form of the IL-11Rα (sIL-11Rα) in combination with IL-11 acts as an agonist on cells expressing ...
Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic heterogeneity, as well as the difficulty in the establishment of the inheritance pattern, often result in a dela...
ATS is safe, fast, efficient, and does not induce resistance easily, it has become one of the first-line drugs recommended by the WHO for the treatment of malaria.Citation23–26In addition to the treatment of malaria, ATS and its metabolites are also known...
(2) researchers can mutate the degrons or block E3-degron interactions to upregulate the expression of tumor suppressors [12], which may be a feasible way to treat cancer; and (3) chemists can design PROTAC drugs to link a substrate with a predicted binding E3 to form double bonds ...
Biyamina and OK have 16 proteins in common; 14 proteins are specific to the Biyamina secretome. Full size image 2- Secreted proteins form stable complexes To further understand the secretome and its interaction network, protein complexes were separated using two-dimensional BN-SDS-PAGE (blue ...
Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which has been reported to improve cognitive function and memory in patients with dementia. As the underlying mechanism of action of YXT has not been elucidated, we examined the effects of Y
For docking of the natural substrate of 4-aminobutyrate aminotransferase, the substrate molecules were separately saved from a known structure (PDB ID: 4ATQ) [49] as a single molecule in the form of an external aldimine and used as a ligand. For docking with 5AVA aminotransferase, pyridoxal ...
3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for the production of steroidal pharmaceutical int
To effectively develop methods to regulate pGC-A, structural information on the full-length form is needed. However, structural data on the transmembrane and intracellular domains are lacking. This work presents expression and optimization using baculovirus, along with the first purification of ...