was used to quantify mitochondrial potential changes by the staining of JC1, % Cells with mitochondrial membrane loss (dysfunctional mitochondria) corresponding to the % of cells with JC-1 in its green monomers form after treatment at the respective IC50 and IC80 concentrations of the complexes. ...
Here, we used drug screening, in vitro and in vivo assays to filter out that doxorubicin and its liposomal form pegylated liposome doxorubicin (PLD) showed synergistic anti-tumor effects in combination with FAK inhibitor IN10018. We hypothesized that anti-tumor immunity and immunogenic cell death ...
Revised phylogeny and novel horizontally acquired virulence determinants of the model soft rot phytopathogen Pectobacterium wasabiae SCC3193. PLoS Pathog. 2012;8:e1003013. Article CAS PubMed PubMed Central Google Scholar Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascueña AM, et ...
Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) as clinical treatments. ATO, which has become the first-line therapeutic agent...
Lianqi Capsule is a PHD used for treating lung, liver, and esophageal cancers. In advanced ESCC patients, the combination of Lianqi Capsule and radiotherapy significantly lowered serum levels of three tumor markers (CEA, SCC-Ag, and CYFRA21-1), and showed more potent effects than radiotherapy...
Modulation of the immunosuppression was another strategy investigated to prevent skin cancer formation. Compared to other immunosuppressants, mammalian target of rapamycin inhibitors (mTORi), such as sirolimus (rapamycin) or everolimus, have suggested protective effects on SCC or BCC incidence [21]. In...
Spatial ability is defined as a cognitive or intellectual skill used to represent, transform, generate, and recall information of an object or the environment. Individual differences across spatial tasks have been strongly linked to science, technology,
To assess the consistency of GPDS ranked lists, we calculated Spearman correlation coefficients (SCC) between GPDS representations of the same drug but constructed from distinct drug viability datasets. Figure S1 (Additional file 1) shows a substantial similarity in GPDS rankings of the same drug ...
Additionally, challenges in designing the Shore Control Center (SCC) for MASS were addressed by (Dybvik et al. Citation2020), with a focus on human-machine interaction. The paper emphasised that optimising human-system interfaces is critical for operators to maintain situational awareness and make ...
which commonly takes the form of a self-titled "spider web assembly" in the laboratory, in which many tubes and wires attach the different pieces to one another. Furthermore, the microfluidic assembly favors a broad range of substrate elements, such as silicon, glass, and polymers like polydi...