In blood and urine, [68Ga]Ga-PSMA-Tz existed mainly in the form of the parent compound at 60 min p.i. (Additional file 1: Figure S13). The excellent stability both in vitro and in vivo provided prerequisites to realize the click-mediated pre-targeted in vivo. [68Ga]Ga-PSMA-Tz ...
The genomes of these cultured methanogens have yielded fundamental insights into the biology of Methanomassiliicoccales [26,29,30,31,32]. Nevertheless, research on members of the order Methanomassiliicoccales has progressed slowly owing to difficulties in their isolation and cultivation process, and...
astrocytes, pericytes, and nerve cells, is a complex obstacle for drug delivery in the treatment of nervous system diseases. This barrier was initially identified by Paul Ehrlich in 1885 [6]. BCECs are the main component of the BBB responsible for selective permeability to small ...
The field of microbiome research has evolved rapidly over the past few decades and has become a topic of great scientific and public interest. As a result of this rapid growth in interest covering different fields, we are lacking a clear commonly agreed definition of the term “microbiome.” ...
the Zooarchaeological EvidenceAntioxidants in Animal Production, Reproduction, Health and WelfareApplication of Geometric Morphometrics to Understand Vertebrate and Invertebrate Morphological DiversityBacterial Aquaculture PathologyBacterial Diseases in Livestock and PoultryBee Biology, Pathology and ManagementBiodiversity...
The gut microbiome of domestic animals carries antibiotic resistance genes (ARGs) which can be transmitted to the environment and humans, resulting in challenges of antibiotic resistance. Although it has been reported that the rumen microbiome of ruminan
in environmental conditions and a considerable proportion of precipitation as rain [13,14]. In the continental Antarctica, precipitation occurs almost entirely in the form of snow and is often extremely limited. In some parts of the continent where low atmospheric humidity is typical, much of this...
Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those from obese individuals (O-ADSCs) have not bee
DNA in the nucleus is highly folded and condensed to form chromatin with a specific three-dimensional advanced structure, rather than a single linear structure. This form of existence ensures that DNA remains stable as genetic material. The purpose of genomics is to collectively characterize and qua...
Nanomedicine and nanomaterials in anticancer therapy Nanomedicine refers to use of nanotechnology to make drugs into nanoparticles with particle size between 1 and 100 nm, or the combination of appropriate carrier materials with bulk drugs to form nanoparticles with nanometer scale and the final pharmaceu...