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There is limited research on studying the usage patterns and affordability of orphan drugs in a specific region in China using Real World Data (RWD). However, changes in indicators such as frequency of medical insurance claims, medication cost, defined daily doses (DDDs), defined daily drug ...
28,29,30]. A clinical study revealed that intrathecal administration of antisense oligonucleotides (ASO) can decrease the levels of mutant huntingtin protein (mHTT) in the cerebrospinal fluid of Huntington's disease (HD) patients, and other studies also have...
prevent or treat Long COVID, observational analyses, using appropriate methods that are designed to leverage the complexity, including missing data, and large sample sizes characteristic of EHR real-world data (RWD) can provide early insights regarding the relationship between SSRI use and Long CO...
The final conceptual model is illustrated in influence diagram form (Fig. 3). This proposed model will facilitate the improvement of clinical and economic representation of CMD, where metabolic dysfunction conditions could lead to various events including both CVD and T2DM. Fig. 3 Final conceptual ...
[23], cardiac organoids derived from hiPSCs possess cardiomyocytes, endothelial cells, and mesenchymal cells and can form chamber-like structures [30, 31]. These organoids can also spontaneously contract in a rhythmic pattern. In simulating RIHD, cardiac organoids have an advantage over ...
A model of CCI was established via 2VO. Briefly, each rat was anesthetized by inhaling isoflurane (3% for induction, 1.5% for maintenance, 0.6 l/min oxygen flow; RWD, China) and placed on an animal operating table on which a heating pad was placed to maintain body temperature at 37 °...
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Hearing and vision loss is highly prevalent in residents with dementia (RwD) living in long-term care (LTC) facilities. Sensory loss often has a negative impact on quality of life and other dementia-related outcomes. Optimising sensory function may impro