Sequences were demultiplexed using QIIME, followed by quality control and taxonomy assignment using Dada2 package (R Studio v.3.6.3) and the RDP 16S rRNA gene operational taxonomic unit (OTU) reference database. The taxonomic categories were refined by BLAST [58] searches of any unassigned seque...
The rate of relapse has also been a question among children treated with RUTF. With deficiency of iron recognized in malnourished children [18], galactooligosaccharides (GOS), a form of prebiotic, have been proven to have anti-inflammatory and antimicrobial actions that might enhance response to ...
The eradication of Plasmodium vivax malaria is complicated due to the presence of hypnozoites, the hidden dormant form of the parasite that is present in the liver. Currently available drug regimens are effective at killing hypnozoites but cause side effects and are difficult to administer. Studie...
Cardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated in diabetic hearts. Deletion of RIPK3 was reported to attenuate myocardial injury and heart dysfunction in strepto
This process facilitates the release of pro-apoptotic substances into the cytoplasm from the IMS, such as Cyt C [24]. Once in the cytoplasm, Cyt C binds to apoptotic peptidase activating factor 1 and procaspase-9 to form an apoptosome, initiating the caspase cascade reaction and leading to ...
However, the efficacy of ERT is limited when addressing neurological symptoms in type 2 and 3 GDs due to the inability of recombinant enzymes to cross the blood-brain barrier (BBB) [7]. Consequently, systemically administered enzymes fail to reach the brain parenchyma, leaving GD patients with ...
Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remain less clear, due to the confounding effects of geography and methodology in investigations of populations studied to date. Furthermor
Hydrogen-rich water (HRW) is a form of potable water that has been super-saturated with molecular hydrogen gas (H2) through pressurized dissolution [6]. The hydrogen molecules are extremely small, so they can easily penetrate water and stay dissolved for a while. In recent years, it has bee...
Furthermore, SP-A response patterns in proteins related to regulation of inflammation (ROI) and regulatory/developmental function (RDP) were similar in both sexes. However, in two cases we observed marked differences in the response patterns between sexes – especially in proteins involved in ...
The DEL phenotype is a D variant with a low number of D antigens per red cell [1,8,9]. Patients and donors with a DEL phenotype are routinely typed as RhD-negative in blood group serology, although they carry the D antigen. They should be considered RhD-positive for several clinically...