22]. Emerging researches demonstrated that manganese ions (Mn2+) as a catalytic cofactor binding to cGAS, also participate in activating innate immunity via the imperative activation of the cGAS-STING signaling pathway in a dsDNA-independent mode [23,24,25]. Given the ...
The eradication of Plasmodium vivax malaria is complicated due to the presence of hypnozoites, the hidden dormant form of the parasite that is present in the liver. Currently available drug regimens are effective at killing hypnozoites but cause side effects and are difficult to administer. Studie...
They fulfill a vital role in cellular processes by serving as the primary source of ATP synthesis, controlling the creation of reactive oxygen species (ROS), facilitating intracellular Ca2+ cycling, and participating in apoptosis [1]. The occurrence of even a minor disruption in any of the mitoc...
Angelica polysaccharides (AP) have numerous benefits in relieving type 2 diabetes (T2D). However, the underlying mechanisms have yet to be fully understood. Recent many reports have suggested that altering gut microbiota can have adverse effects on the h
In the oral cavity, the gingiva hosts millions of microbes in the form of biofilms which are complex and dynamic microbial communities in terms of spatial structures and compositions. These communities continuously interact with the gingiva and influence oral health and disease: homeostatic host-microbe...
(1) This study was part of the UNRAVEL RDP. (2) The project has been approved by the Biobank Board of the Medical Ethics Committee of the University Medical Center Utrecht. (3) The approval number is 12-387 UNRAVEL Biobank. (4) The project has been approved in 2018. Informed consent ...
Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders. Ho
A unique sequence in the KIR locus is located in the 14 kb intergenic region that separates KIR3DP1 from KIR2DL4 and divides the locus into centromeric and telomeric segments of similar size[7, 9]. This unique sequence has been the site for events of reciprocal recombination to form new ...
However, the efficacy of ERT is limited when addressing neurological symptoms in type 2 and 3 GDs due to the inability of recombinant enzymes to cross the blood-brain barrier (BBB) [7]. Consequently, systemically administered enzymes fail to reach the brain parenchyma, leaving GD patients with ...
Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell drainage and lymphatic vasculature, implicat